Variability of gonadotropin response to luteinizing hormone-releasing hormone in amenorrheic women

Pier Giorgio Crosignani, Eugenio Reschini, Alberto D'Alberton, Letizia Trojsi, Luigi Cantalamessa, Gianni Giustina

Research output: Contribution to journalArticle

Abstract

Plasma gonadotropin response to luteinizing hormone-releasing hormone (LH-RH) (200 μg intravenously) has been evaluated in a group of amenorrheic women. Eleven of them had primary amenorrhea due to isolated gonadotropin deficiency. Fifteen had secondary functional amenorrhea; this group included patients with anorexia nervosa, polycystic ovary, amenorrhea-galactorrhea, idiopathic amenorrhea. Most patients showed a significant elevation of gonadotropin plasma levels after LH-RH injection. However, a marked variability in luteinizing hormone (LH) and follicle-stimulating hormone (FSH) rise was observed. The two groups included both patients with normal LH response and patients with blunted LH response. An evident FSH elevation has been found in the great majority of subjects. A frequent pattern of anomalous response observed in amenorrheic women was the occurrence of a blunted LH response associated with a markedly elevated FSH response.

Original languageEnglish
Pages (from-to)376-384
Number of pages9
JournalAmerican Journal of Obstetrics and Gynecology
Volume120
Issue number3
Publication statusPublished - Oct 1 1974

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynaecology

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    Crosignani, P. G., Reschini, E., D'Alberton, A., Trojsi, L., Cantalamessa, L., & Giustina, G. (1974). Variability of gonadotropin response to luteinizing hormone-releasing hormone in amenorrheic women. American Journal of Obstetrics and Gynecology, 120(3), 376-384.