Variable electrobehavioral patterns during focal nonconvulsive status epilepticus induced by unilateral intrahippocampal injection of kainic acid

Salvatore Arcieri, Rosa Velotti, Francesco Noè, Giovanni Carriero, Alessandro Cattalini, Barbara Galbardi, Vadym Gnatkovsky, Marco De Curtis

Research output: Contribution to journalArticlepeer-review

Abstract

Objective Nonconvulsive status epilepticus (ncSE) is a severe condition that may result in neurologic sequelae and epilepsy resistant to pharmacologic treatment. We analyze here seizure and electroencephalography (EEG) patterns and their correlation to the development of a chronic epileptic condition in a guinea pig model of focal ncSE induced by intrahippocampal injection of kainic acid (KA). Methods Electrobehavioral patterns during ncSE induced by unilateral injection of 1 μg of KA in the CA1 region of the hippocampus were characterized by continuous video-EEG monitoring in 13 guinea pigs bilaterally implanted with recording electrodes in the hippocampus and neocortex. Results Video-EEG analysis demonstrates a high variability of seizure type and duration during KA-induced ncSE. Seizures showed focal signs correlated with diverse epileptiform EEG discharge distributions, either diffuse or localized. Nonfocal (bilateral motor) signs during seizures most likely correlated with a diffuse EEG pattern. The evolution into a chronic epileptic condition correlated neither with the severity of seizure pattern nor with the diffusion of the EEG discharges observed during the ncSE. Significance Video-EEG monitoring in a guinea pig model of ncSE induced by unilateral hippocampal injection of KA demonstrates a high variability of electrobehavioral patterns. We demonstrate that the seizure severity score during focal ncSE is not a predictor of the evolution into a chronic epileptic condition of mesial temporal lobe epilepsy.

Original languageEnglish
Pages (from-to)1978-1985
Number of pages8
JournalEpilepsia
Volume55
Issue number12
DOIs
Publication statusPublished - Dec 1 2014

Keywords

  • Guinea pig
  • Intrahippocampal kainic acid
  • Seizures
  • Temporal lobe epilepsy model

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Medicine(all)

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