Variable expression patterns of Mycobacterium tuberculosis PE_PGRS genes: Evidence that PE_PGRS16 and PE_PGRS26 are inversely regulated in vivo

Veerabadran Dheenadhayalan, Giovanni Delogu, Maurizio Sanguinetti, Giovanni Fadda, Michael J. Brennan

Research output: Contribution to journalArticlepeer-review

Abstract

Evaluation of expression of 16 PE_PGRS genes present in Mycobacterium tuberculosis under various growth conditions demonstrated constitutive expression of 7 genes, variable expression of 7 genes, and no expression of 2 genes. An inverse expression profile for genes PE_PGRS16 and PE_PGRS26 was observed to occur in macrophages and in mice infected with M. tuberculosis. Variable expression of PE_PGRS proteins could have implications for their role in the immunopathogenesis of tuberculosis.

Original languageEnglish
Pages (from-to)3721-3725
Number of pages5
JournalJournal of Bacteriology
Volume188
Issue number10
DOIs
Publication statusPublished - May 2006

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Immunology

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