Variable response to atrial pacing after intravenous propranolol in patients with stable exertional angina

S. De Servi, M. Ferrario, S. Ghio, P. Cioffi, L. Angoli, E. Bramucci, E. Aimè, V. Montericcio, G. Specchia

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of propranolol administration on regional coronary haemodynamics were investigated in 14 patients with stable exertional angina and isolated left anterior descending artery disease. Thermodilution was used to measure great cardiac vein flow (GCVF) and anterior regional coronary resistance (ARCR) under control conditions, at peak atrial pacing, after i.v. propranolol administration (0.1 mg kg-1) and at the peak of repeated atrial pacing. Propranolol did not change peak pacing heart rate, systolic blood pressure or double product. Peak pacing GCVF decreased slightly but non-significantly after drug administration from 84 ± 20 to 79 ± 24 ml min-1, while ARCR increased, but again non-significantly,from 1.36 ± 0.44 to 1.45 ± 0.45. Analysis of individual patient responses revealed that propranolol prolonged peak pacing time and hence peak pacing heart rate (from 126 ± 24 to 140 ± 23 beats min-1, P-1.min, P = ns) while it increased significantly in the nine patients who did not improve after the drug (before propranolol 1.30 ± 0.44, after propranolol 1.48 ± 0.41 mmHg.ml-1.min,P

Original languageEnglish
Pages (from-to)997-1005
Number of pages9
JournalEuropean Heart Journal
Volume11
Issue number11
Publication statusPublished - 1990

Keywords

  • Angina pectoris
  • Atrial pacing
  • Coronary haemodynamics
  • Propranolol

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Physiology

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