Variant of ataxia-telangiectasia with low-level radiosensitivity

M. Fiorilli, A. Antonelli, G. Russo, M. Crescenzi, M. Carbonari, P. Petrinelli

Research output: Contribution to journalArticlepeer-review


In the present study we examined cells from several patients clinically diagnosed as having ataxia-telangiectasia (AT), for the capacity of their cells to inhibit DNA synthesis following exposure to gamma irradiation, and for the rate of spontaneous or blcomycin-induced chromosomal aberrations. Cells from two patients showed normal inhibition of DNA synthesis and levels of induced chromosomal aberrations intermediate between normal and AT cells. These two patients had only minimal immunologic impairment. These findings appear to define one distinct subset of AT.

Original languageEnglish
Pages (from-to)274-277
Number of pages4
JournalHuman Genetics
Issue number3
Publication statusPublished - Jul 1985

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics


Dive into the research topics of 'Variant of ataxia-telangiectasia with low-level radiosensitivity'. Together they form a unique fingerprint.

Cite this