TY - JOUR
T1 - Variation in lamotrigine plasma concentrations with hormonal contraceptive monthly cycles in patients with epilepsy
AU - Contin, Manuela
AU - Albani, Fiorenzo
AU - Ambrosetto, Giovanni
AU - Avoni, Patrizia
AU - Bisulli, Francesca
AU - Riva, Roberto
AU - Tinuper, Paolo
AU - Baruzzi, Agostino
PY - 2006/9
Y1 - 2006/9
N2 - Purpose: This is the first report comparing intrasubject lamotrigine (LTG) plasma concentrations between hormonal contraceptive (HC) intake and week-off phases in epilepsy patients receiving combined LTG and HC treatment. We describe the variation in LTG plasma concentrations with hormonal contraceptive (HC) monthly intake cycles in a series of eight patients with epilepsy. Methods: Venous blood samples were prospectively drawn from patients before their first morning dose of LTG, once between days 18 and 21 of HC intake and once between days 5 and 7 of the HC-free week. Results: Median LTG plasma concentrations were significantly higher during the HC washout week than during the phase of HC intake (p = 0.02). The median value of intrasubject percentage increase was 27%, with a wide interpatient variability. Conclusions: These findings are in line with a preliminary report on healthy volunteers. Standardization of blood sampling in relation to HC intake cycles is advisable when planning LTG therapeutic monitoring in patients receiving HC.
AB - Purpose: This is the first report comparing intrasubject lamotrigine (LTG) plasma concentrations between hormonal contraceptive (HC) intake and week-off phases in epilepsy patients receiving combined LTG and HC treatment. We describe the variation in LTG plasma concentrations with hormonal contraceptive (HC) monthly intake cycles in a series of eight patients with epilepsy. Methods: Venous blood samples were prospectively drawn from patients before their first morning dose of LTG, once between days 18 and 21 of HC intake and once between days 5 and 7 of the HC-free week. Results: Median LTG plasma concentrations were significantly higher during the HC washout week than during the phase of HC intake (p = 0.02). The median value of intrasubject percentage increase was 27%, with a wide interpatient variability. Conclusions: These findings are in line with a preliminary report on healthy volunteers. Standardization of blood sampling in relation to HC intake cycles is advisable when planning LTG therapeutic monitoring in patients receiving HC.
KW - Antiepileptic drug interactions
KW - Epilepsy
KW - Hormonal contraceptives
KW - Lamotrigine
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U2 - 10.1111/j.1528-1167.2006.00558.x
DO - 10.1111/j.1528-1167.2006.00558.x
M3 - Article
C2 - 16981875
AN - SCOPUS:33748684235
VL - 47
SP - 1573
EP - 1575
JO - Epilepsia
JF - Epilepsia
SN - 0013-9580
IS - 9
ER -