Variation in the ADIPOQ gene promoter is associated with carotid intima media thickness independent of plasma adiponectin levels in healthy subjects

Sheila Patel, Allan Flyvbjerg, Michaela Kozàkovà, Jan Frystyk, Ibrahim M. Ibrahim, John R. Petrie, Peter J. Avery, Ele Ferrannini, Mark Walker, R. J. Heine, J. Dekker, G. Nijpels, W. Boorsma, A. Mitrakou, S. Tournis, K. Kyriakopoulou, P. Thomakos, N. Lalic, K. Lalic, A. Jotic & 127 others L. Lukic, M. Civcic, J. Nolan, T. P. Yeow, M. Murphy, C. DeLong, G. Neary, M. P. Colgan, M. Hatunic, T. Konrad, H. Böhles, S. Fuellert, F. Baer, H. Zuchhold, A. Golay, E. Harsch Bobbioni, V. Barthassat, V. Makoundou, T. N O Lehmann, T. Merminod, J. R. Petrie, C. Perry, F. Neary, C. MacDougall, K. Shields, L. Malcolm, M. Laakso, U. Salmenniemi, A. Aura, R. Raisanen, U. Ruotsalainen, T. Sistonen, M. Laitinen, H. Saloranta, S. W. Coppack, N. McIntosh, P. Khadobaksh, M. Laville, F. Bonnet, A. Brac De La Perriere, C. Louche-Pelissier, C. Maitrepierre, J. Peyrat, A. Serusclat, R. Gabriel, E. M. Sánchez, R. Carraro, A. Friera, B. Novella, P. Nilsson, M. Persson, G. Östling, O. Melander, P. Burri, P. M. Piatti, L. D. Monti, E. Setola, E. Galluccio, F. Minicucci, A. Colleluori, M. Walker, I. M. Ibrahim, M. Jayapaul, D. Carman, K. Short, Y. McGrady, D. Richardson, H. Beck-Nielsen, P. Staehr, K. Hojlund, V. Vestergaard, C. Olsen, L. Hansen, G. B. Bolli, F. Porcellati, C. Fanelli, P. Lucidi, F. Calcinaro, A. Saturni, E. Ferrannini, A. Natali, E. Muscelli, S. Pinnola, M. Kozakova, B. D. Astiarraga, G. Mingrone, C. Guidone, A. Favuzzi, P. Di Rocco, C. Anderwald, M. Bischof, M. Promintzer, M. Krebs, M. Mandl, A. Hofer, A. Luger, W. Waldhäusl, M. Roden, B. Balkau, S. W. Coppack, J. M. Dekker, E. Ferrannini, A. Mari, A. Natali, M. Walker, P. Gaffney, J. Nolan, G. Boran, C. Olsen, L. Hansen, H. Beck-Nielsen, A. Kok, J. Dekker, S. Patel, M. Walker, A. Gastaldelli, D. Ciociaro, M. Kozakova, M. T. Guillanneuf, B. Balkau, L. Mhamdi, A. Mari, G. Pacini, C. Cavaggion, S. A. Hills, L. Landucci, L. Mota

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Aims: The ADIPOQ gene encodes the protein adiponectin, and decreased circulating adiponectin levels have been observed in cardiovascular disease. We investigated the role of the ADIPOQ gene single-nucleotide polymorphisms (SNPs) A-11426G, G-11391A, C-11377G, and T45G with plasma adiponectin levels and common carotid artery intima media thickness (IMT) in a cohort of healthy subjects participating in the RISC (Relationship between Insulin Sensitivity and Cardiovascular disease) study. Methods and results: Anthropometric and metabolic assessment and B-mode ultrasound of the carotid IMT were measured in 1306 subjects [589 men; 717 women, mean ± SD age 43.8 ± 8.3 years, BMI 25.5 ± 4.0 kg/m2] recruited from 19 centres in 14 European countries. Carriers of the -11426G allele and homozygous carriers of the -11391G allele had significantly lower plasma adiponectin levels. These relationships remained significant after adjusting for age, sex, recruitment centre, and BMI. Carriers of SNP -11377G allele had significantly greater IMT values compared with C allele homozygotes [geometric mean (interquartile range) 601 (543-665) vs. 590 (537-647) μm, P = 0.021]. This relationship became stronger after correcting for key covariates, including plasma adiponectin levels (P = 0.011). Conclusion: Variation within the ADIPOQ gene promoter is directly associated with carotid IMT in healthy subjects and is independent of circulating adiponectin levels.

Original languageEnglish
Pages (from-to)386-393
Number of pages8
JournalEuropean Heart Journal
Volume29
Issue number3
DOIs
Publication statusPublished - Feb 2008

Fingerprint

Carotid Intima-Media Thickness
Adiponectin
Healthy Volunteers
Alleles
Genes
Single Nucleotide Polymorphism
Cardiovascular Diseases
Common Carotid Artery
Homozygote
Insulin Resistance
Proteins

Keywords

  • Adiponectin
  • ADIPOQ gene
  • Carotid intima media thickness
  • Genetics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Variation in the ADIPOQ gene promoter is associated with carotid intima media thickness independent of plasma adiponectin levels in healthy subjects. / Patel, Sheila; Flyvbjerg, Allan; Kozàkovà, Michaela; Frystyk, Jan; Ibrahim, Ibrahim M.; Petrie, John R.; Avery, Peter J.; Ferrannini, Ele; Walker, Mark; Heine, R. J.; Dekker, J.; Nijpels, G.; Boorsma, W.; Mitrakou, A.; Tournis, S.; Kyriakopoulou, K.; Thomakos, P.; Lalic, N.; Lalic, K.; Jotic, A.; Lukic, L.; Civcic, M.; Nolan, J.; Yeow, T. P.; Murphy, M.; DeLong, C.; Neary, G.; Colgan, M. P.; Hatunic, M.; Konrad, T.; Böhles, H.; Fuellert, S.; Baer, F.; Zuchhold, H.; Golay, A.; Harsch Bobbioni, E.; Barthassat, V.; Makoundou, V.; Lehmann, T. N O; Merminod, T.; Petrie, J. R.; Perry, C.; Neary, F.; MacDougall, C.; Shields, K.; Malcolm, L.; Laakso, M.; Salmenniemi, U.; Aura, A.; Raisanen, R.; Ruotsalainen, U.; Sistonen, T.; Laitinen, M.; Saloranta, H.; Coppack, S. W.; McIntosh, N.; Khadobaksh, P.; Laville, M.; Bonnet, F.; Brac De La Perriere, A.; Louche-Pelissier, C.; Maitrepierre, C.; Peyrat, J.; Serusclat, A.; Gabriel, R.; Sánchez, E. M.; Carraro, R.; Friera, A.; Novella, B.; Nilsson, P.; Persson, M.; Östling, G.; Melander, O.; Burri, P.; Piatti, P. M.; Monti, L. D.; Setola, E.; Galluccio, E.; Minicucci, F.; Colleluori, A.; Walker, M.; Ibrahim, I. M.; Jayapaul, M.; Carman, D.; Short, K.; McGrady, Y.; Richardson, D.; Beck-Nielsen, H.; Staehr, P.; Hojlund, K.; Vestergaard, V.; Olsen, C.; Hansen, L.; Bolli, G. B.; Porcellati, F.; Fanelli, C.; Lucidi, P.; Calcinaro, F.; Saturni, A.; Ferrannini, E.; Natali, A.; Muscelli, E.; Pinnola, S.; Kozakova, M.; Astiarraga, B. D.; Mingrone, G.; Guidone, C.; Favuzzi, A.; Di Rocco, P.; Anderwald, C.; Bischof, M.; Promintzer, M.; Krebs, M.; Mandl, M.; Hofer, A.; Luger, A.; Waldhäusl, W.; Roden, M.; Balkau, B.; Coppack, S. W.; Dekker, J. M.; Ferrannini, E.; Mari, A.; Natali, A.; Walker, M.; Gaffney, P.; Nolan, J.; Boran, G.; Olsen, C.; Hansen, L.; Beck-Nielsen, H.; Kok, A.; Dekker, J.; Patel, S.; Walker, M.; Gastaldelli, A.; Ciociaro, D.; Kozakova, M.; Guillanneuf, M. T.; Balkau, B.; Mhamdi, L.; Mari, A.; Pacini, G.; Cavaggion, C.; Hills, S. A.; Landucci, L.; Mota, L.

In: European Heart Journal, Vol. 29, No. 3, 02.2008, p. 386-393.

Research output: Contribution to journalArticle

Patel, S, Flyvbjerg, A, Kozàkovà, M, Frystyk, J, Ibrahim, IM, Petrie, JR, Avery, PJ, Ferrannini, E, Walker, M, Heine, RJ, Dekker, J, Nijpels, G, Boorsma, W, Mitrakou, A, Tournis, S, Kyriakopoulou, K, Thomakos, P, Lalic, N, Lalic, K, Jotic, A, Lukic, L, Civcic, M, Nolan, J, Yeow, TP, Murphy, M, DeLong, C, Neary, G, Colgan, MP, Hatunic, M, Konrad, T, Böhles, H, Fuellert, S, Baer, F, Zuchhold, H, Golay, A, Harsch Bobbioni, E, Barthassat, V, Makoundou, V, Lehmann, TNO, Merminod, T, Petrie, JR, Perry, C, Neary, F, MacDougall, C, Shields, K, Malcolm, L, Laakso, M, Salmenniemi, U, Aura, A, Raisanen, R, Ruotsalainen, U, Sistonen, T, Laitinen, M, Saloranta, H, Coppack, SW, McIntosh, N, Khadobaksh, P, Laville, M, Bonnet, F, Brac De La Perriere, A, Louche-Pelissier, C, Maitrepierre, C, Peyrat, J, Serusclat, A, Gabriel, R, Sánchez, EM, Carraro, R, Friera, A, Novella, B, Nilsson, P, Persson, M, Östling, G, Melander, O, Burri, P, Piatti, PM, Monti, LD, Setola, E, Galluccio, E, Minicucci, F, Colleluori, A, Walker, M, Ibrahim, IM, Jayapaul, M, Carman, D, Short, K, McGrady, Y, Richardson, D, Beck-Nielsen, H, Staehr, P, Hojlund, K, Vestergaard, V, Olsen, C, Hansen, L, Bolli, GB, Porcellati, F, Fanelli, C, Lucidi, P, Calcinaro, F, Saturni, A, Ferrannini, E, Natali, A, Muscelli, E, Pinnola, S, Kozakova, M, Astiarraga, BD, Mingrone, G, Guidone, C, Favuzzi, A, Di Rocco, P, Anderwald, C, Bischof, M, Promintzer, M, Krebs, M, Mandl, M, Hofer, A, Luger, A, Waldhäusl, W, Roden, M, Balkau, B, Coppack, SW, Dekker, JM, Ferrannini, E, Mari, A, Natali, A, Walker, M, Gaffney, P, Nolan, J, Boran, G, Olsen, C, Hansen, L, Beck-Nielsen, H, Kok, A, Dekker, J, Patel, S, Walker, M, Gastaldelli, A, Ciociaro, D, Kozakova, M, Guillanneuf, MT, Balkau, B, Mhamdi, L, Mari, A, Pacini, G, Cavaggion, C, Hills, SA, Landucci, L & Mota, L 2008, 'Variation in the ADIPOQ gene promoter is associated with carotid intima media thickness independent of plasma adiponectin levels in healthy subjects', European Heart Journal, vol. 29, no. 3, pp. 386-393. https://doi.org/10.1093/eurheartj/ehm526
Patel, Sheila ; Flyvbjerg, Allan ; Kozàkovà, Michaela ; Frystyk, Jan ; Ibrahim, Ibrahim M. ; Petrie, John R. ; Avery, Peter J. ; Ferrannini, Ele ; Walker, Mark ; Heine, R. J. ; Dekker, J. ; Nijpels, G. ; Boorsma, W. ; Mitrakou, A. ; Tournis, S. ; Kyriakopoulou, K. ; Thomakos, P. ; Lalic, N. ; Lalic, K. ; Jotic, A. ; Lukic, L. ; Civcic, M. ; Nolan, J. ; Yeow, T. P. ; Murphy, M. ; DeLong, C. ; Neary, G. ; Colgan, M. P. ; Hatunic, M. ; Konrad, T. ; Böhles, H. ; Fuellert, S. ; Baer, F. ; Zuchhold, H. ; Golay, A. ; Harsch Bobbioni, E. ; Barthassat, V. ; Makoundou, V. ; Lehmann, T. N O ; Merminod, T. ; Petrie, J. R. ; Perry, C. ; Neary, F. ; MacDougall, C. ; Shields, K. ; Malcolm, L. ; Laakso, M. ; Salmenniemi, U. ; Aura, A. ; Raisanen, R. ; Ruotsalainen, U. ; Sistonen, T. ; Laitinen, M. ; Saloranta, H. ; Coppack, S. W. ; McIntosh, N. ; Khadobaksh, P. ; Laville, M. ; Bonnet, F. ; Brac De La Perriere, A. ; Louche-Pelissier, C. ; Maitrepierre, C. ; Peyrat, J. ; Serusclat, A. ; Gabriel, R. ; Sánchez, E. M. ; Carraro, R. ; Friera, A. ; Novella, B. ; Nilsson, P. ; Persson, M. ; Östling, G. ; Melander, O. ; Burri, P. ; Piatti, P. M. ; Monti, L. D. ; Setola, E. ; Galluccio, E. ; Minicucci, F. ; Colleluori, A. ; Walker, M. ; Ibrahim, I. M. ; Jayapaul, M. ; Carman, D. ; Short, K. ; McGrady, Y. ; Richardson, D. ; Beck-Nielsen, H. ; Staehr, P. ; Hojlund, K. ; Vestergaard, V. ; Olsen, C. ; Hansen, L. ; Bolli, G. B. ; Porcellati, F. ; Fanelli, C. ; Lucidi, P. ; Calcinaro, F. ; Saturni, A. ; Ferrannini, E. ; Natali, A. ; Muscelli, E. ; Pinnola, S. ; Kozakova, M. ; Astiarraga, B. D. ; Mingrone, G. ; Guidone, C. ; Favuzzi, A. ; Di Rocco, P. ; Anderwald, C. ; Bischof, M. ; Promintzer, M. ; Krebs, M. ; Mandl, M. ; Hofer, A. ; Luger, A. ; Waldhäusl, W. ; Roden, M. ; Balkau, B. ; Coppack, S. W. ; Dekker, J. M. ; Ferrannini, E. ; Mari, A. ; Natali, A. ; Walker, M. ; Gaffney, P. ; Nolan, J. ; Boran, G. ; Olsen, C. ; Hansen, L. ; Beck-Nielsen, H. ; Kok, A. ; Dekker, J. ; Patel, S. ; Walker, M. ; Gastaldelli, A. ; Ciociaro, D. ; Kozakova, M. ; Guillanneuf, M. T. ; Balkau, B. ; Mhamdi, L. ; Mari, A. ; Pacini, G. ; Cavaggion, C. ; Hills, S. A. ; Landucci, L. ; Mota, L. / Variation in the ADIPOQ gene promoter is associated with carotid intima media thickness independent of plasma adiponectin levels in healthy subjects. In: European Heart Journal. 2008 ; Vol. 29, No. 3. pp. 386-393.
@article{f29429f969e04d6fa1a2cf3a9d36ea94,
title = "Variation in the ADIPOQ gene promoter is associated with carotid intima media thickness independent of plasma adiponectin levels in healthy subjects",
abstract = "Aims: The ADIPOQ gene encodes the protein adiponectin, and decreased circulating adiponectin levels have been observed in cardiovascular disease. We investigated the role of the ADIPOQ gene single-nucleotide polymorphisms (SNPs) A-11426G, G-11391A, C-11377G, and T45G with plasma adiponectin levels and common carotid artery intima media thickness (IMT) in a cohort of healthy subjects participating in the RISC (Relationship between Insulin Sensitivity and Cardiovascular disease) study. Methods and results: Anthropometric and metabolic assessment and B-mode ultrasound of the carotid IMT were measured in 1306 subjects [589 men; 717 women, mean ± SD age 43.8 ± 8.3 years, BMI 25.5 ± 4.0 kg/m2] recruited from 19 centres in 14 European countries. Carriers of the -11426G allele and homozygous carriers of the -11391G allele had significantly lower plasma adiponectin levels. These relationships remained significant after adjusting for age, sex, recruitment centre, and BMI. Carriers of SNP -11377G allele had significantly greater IMT values compared with C allele homozygotes [geometric mean (interquartile range) 601 (543-665) vs. 590 (537-647) μm, P = 0.021]. This relationship became stronger after correcting for key covariates, including plasma adiponectin levels (P = 0.011). Conclusion: Variation within the ADIPOQ gene promoter is directly associated with carotid IMT in healthy subjects and is independent of circulating adiponectin levels.",
keywords = "Adiponectin, ADIPOQ gene, Carotid intima media thickness, Genetics",
author = "Sheila Patel and Allan Flyvbjerg and Michaela Koz{\`a}kov{\`a} and Jan Frystyk and Ibrahim, {Ibrahim M.} and Petrie, {John R.} and Avery, {Peter J.} and Ele Ferrannini and Mark Walker and Heine, {R. J.} and J. Dekker and G. Nijpels and W. Boorsma and A. Mitrakou and S. Tournis and K. Kyriakopoulou and P. Thomakos and N. Lalic and K. Lalic and A. Jotic and L. Lukic and M. Civcic and J. Nolan and Yeow, {T. P.} and M. Murphy and C. DeLong and G. Neary and Colgan, {M. P.} and M. Hatunic and T. Konrad and H. B{\"o}hles and S. Fuellert and F. Baer and H. Zuchhold and A. Golay and {Harsch Bobbioni}, E. and V. Barthassat and V. Makoundou and Lehmann, {T. N O} and T. Merminod and Petrie, {J. R.} and C. Perry and F. Neary and C. MacDougall and K. Shields and L. Malcolm and M. Laakso and U. Salmenniemi and A. Aura and R. Raisanen and U. Ruotsalainen and T. Sistonen and M. Laitinen and H. Saloranta and Coppack, {S. W.} and N. McIntosh and P. Khadobaksh and M. Laville and F. Bonnet and {Brac De La Perriere}, A. and C. Louche-Pelissier and C. Maitrepierre and J. Peyrat and A. Serusclat and R. Gabriel and S{\'a}nchez, {E. M.} and R. Carraro and A. Friera and B. Novella and P. Nilsson and M. Persson and G. {\"O}stling and O. Melander and P. Burri and Piatti, {P. M.} and Monti, {L. D.} and E. Setola and E. Galluccio and F. Minicucci and A. Colleluori and M. Walker and Ibrahim, {I. M.} and M. Jayapaul and D. Carman and K. Short and Y. McGrady and D. Richardson and H. Beck-Nielsen and P. Staehr and K. Hojlund and V. Vestergaard and C. Olsen and L. Hansen and Bolli, {G. B.} and F. Porcellati and C. Fanelli and P. Lucidi and F. Calcinaro and A. Saturni and E. Ferrannini and A. Natali and E. Muscelli and S. Pinnola and M. Kozakova and Astiarraga, {B. D.} and G. Mingrone and C. Guidone and A. Favuzzi and {Di Rocco}, P. and C. Anderwald and M. Bischof and M. Promintzer and M. Krebs and M. Mandl and A. Hofer and A. Luger and W. Waldh{\"a}usl and M. Roden and B. Balkau and Coppack, {S. W.} and Dekker, {J. M.} and E. Ferrannini and A. Mari and A. Natali and M. Walker and P. Gaffney and J. Nolan and G. Boran and C. Olsen and L. Hansen and H. Beck-Nielsen and A. Kok and J. Dekker and S. Patel and M. Walker and A. Gastaldelli and D. Ciociaro and M. Kozakova and Guillanneuf, {M. T.} and B. Balkau and L. Mhamdi and A. Mari and G. Pacini and C. Cavaggion and Hills, {S. A.} and L. Landucci and L. Mota",
year = "2008",
month = "2",
doi = "10.1093/eurheartj/ehm526",
language = "English",
volume = "29",
pages = "386--393",
journal = "European Heart Journal",
issn = "0195-668X",
publisher = "Oxford University Press",
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}

TY - JOUR

T1 - Variation in the ADIPOQ gene promoter is associated with carotid intima media thickness independent of plasma adiponectin levels in healthy subjects

AU - Patel, Sheila

AU - Flyvbjerg, Allan

AU - Kozàkovà, Michaela

AU - Frystyk, Jan

AU - Ibrahim, Ibrahim M.

AU - Petrie, John R.

AU - Avery, Peter J.

AU - Ferrannini, Ele

AU - Walker, Mark

AU - Heine, R. J.

AU - Dekker, J.

AU - Nijpels, G.

AU - Boorsma, W.

AU - Mitrakou, A.

AU - Tournis, S.

AU - Kyriakopoulou, K.

AU - Thomakos, P.

AU - Lalic, N.

AU - Lalic, K.

AU - Jotic, A.

AU - Lukic, L.

AU - Civcic, M.

AU - Nolan, J.

AU - Yeow, T. P.

AU - Murphy, M.

AU - DeLong, C.

AU - Neary, G.

AU - Colgan, M. P.

AU - Hatunic, M.

AU - Konrad, T.

AU - Böhles, H.

AU - Fuellert, S.

AU - Baer, F.

AU - Zuchhold, H.

AU - Golay, A.

AU - Harsch Bobbioni, E.

AU - Barthassat, V.

AU - Makoundou, V.

AU - Lehmann, T. N O

AU - Merminod, T.

AU - Petrie, J. R.

AU - Perry, C.

AU - Neary, F.

AU - MacDougall, C.

AU - Shields, K.

AU - Malcolm, L.

AU - Laakso, M.

AU - Salmenniemi, U.

AU - Aura, A.

AU - Raisanen, R.

AU - Ruotsalainen, U.

AU - Sistonen, T.

AU - Laitinen, M.

AU - Saloranta, H.

AU - Coppack, S. W.

AU - McIntosh, N.

AU - Khadobaksh, P.

AU - Laville, M.

AU - Bonnet, F.

AU - Brac De La Perriere, A.

AU - Louche-Pelissier, C.

AU - Maitrepierre, C.

AU - Peyrat, J.

AU - Serusclat, A.

AU - Gabriel, R.

AU - Sánchez, E. M.

AU - Carraro, R.

AU - Friera, A.

AU - Novella, B.

AU - Nilsson, P.

AU - Persson, M.

AU - Östling, G.

AU - Melander, O.

AU - Burri, P.

AU - Piatti, P. M.

AU - Monti, L. D.

AU - Setola, E.

AU - Galluccio, E.

AU - Minicucci, F.

AU - Colleluori, A.

AU - Walker, M.

AU - Ibrahim, I. M.

AU - Jayapaul, M.

AU - Carman, D.

AU - Short, K.

AU - McGrady, Y.

AU - Richardson, D.

AU - Beck-Nielsen, H.

AU - Staehr, P.

AU - Hojlund, K.

AU - Vestergaard, V.

AU - Olsen, C.

AU - Hansen, L.

AU - Bolli, G. B.

AU - Porcellati, F.

AU - Fanelli, C.

AU - Lucidi, P.

AU - Calcinaro, F.

AU - Saturni, A.

AU - Ferrannini, E.

AU - Natali, A.

AU - Muscelli, E.

AU - Pinnola, S.

AU - Kozakova, M.

AU - Astiarraga, B. D.

AU - Mingrone, G.

AU - Guidone, C.

AU - Favuzzi, A.

AU - Di Rocco, P.

AU - Anderwald, C.

AU - Bischof, M.

AU - Promintzer, M.

AU - Krebs, M.

AU - Mandl, M.

AU - Hofer, A.

AU - Luger, A.

AU - Waldhäusl, W.

AU - Roden, M.

AU - Balkau, B.

AU - Coppack, S. W.

AU - Dekker, J. M.

AU - Ferrannini, E.

AU - Mari, A.

AU - Natali, A.

AU - Walker, M.

AU - Gaffney, P.

AU - Nolan, J.

AU - Boran, G.

AU - Olsen, C.

AU - Hansen, L.

AU - Beck-Nielsen, H.

AU - Kok, A.

AU - Dekker, J.

AU - Patel, S.

AU - Walker, M.

AU - Gastaldelli, A.

AU - Ciociaro, D.

AU - Kozakova, M.

AU - Guillanneuf, M. T.

AU - Balkau, B.

AU - Mhamdi, L.

AU - Mari, A.

AU - Pacini, G.

AU - Cavaggion, C.

AU - Hills, S. A.

AU - Landucci, L.

AU - Mota, L.

PY - 2008/2

Y1 - 2008/2

N2 - Aims: The ADIPOQ gene encodes the protein adiponectin, and decreased circulating adiponectin levels have been observed in cardiovascular disease. We investigated the role of the ADIPOQ gene single-nucleotide polymorphisms (SNPs) A-11426G, G-11391A, C-11377G, and T45G with plasma adiponectin levels and common carotid artery intima media thickness (IMT) in a cohort of healthy subjects participating in the RISC (Relationship between Insulin Sensitivity and Cardiovascular disease) study. Methods and results: Anthropometric and metabolic assessment and B-mode ultrasound of the carotid IMT were measured in 1306 subjects [589 men; 717 women, mean ± SD age 43.8 ± 8.3 years, BMI 25.5 ± 4.0 kg/m2] recruited from 19 centres in 14 European countries. Carriers of the -11426G allele and homozygous carriers of the -11391G allele had significantly lower plasma adiponectin levels. These relationships remained significant after adjusting for age, sex, recruitment centre, and BMI. Carriers of SNP -11377G allele had significantly greater IMT values compared with C allele homozygotes [geometric mean (interquartile range) 601 (543-665) vs. 590 (537-647) μm, P = 0.021]. This relationship became stronger after correcting for key covariates, including plasma adiponectin levels (P = 0.011). Conclusion: Variation within the ADIPOQ gene promoter is directly associated with carotid IMT in healthy subjects and is independent of circulating adiponectin levels.

AB - Aims: The ADIPOQ gene encodes the protein adiponectin, and decreased circulating adiponectin levels have been observed in cardiovascular disease. We investigated the role of the ADIPOQ gene single-nucleotide polymorphisms (SNPs) A-11426G, G-11391A, C-11377G, and T45G with plasma adiponectin levels and common carotid artery intima media thickness (IMT) in a cohort of healthy subjects participating in the RISC (Relationship between Insulin Sensitivity and Cardiovascular disease) study. Methods and results: Anthropometric and metabolic assessment and B-mode ultrasound of the carotid IMT were measured in 1306 subjects [589 men; 717 women, mean ± SD age 43.8 ± 8.3 years, BMI 25.5 ± 4.0 kg/m2] recruited from 19 centres in 14 European countries. Carriers of the -11426G allele and homozygous carriers of the -11391G allele had significantly lower plasma adiponectin levels. These relationships remained significant after adjusting for age, sex, recruitment centre, and BMI. Carriers of SNP -11377G allele had significantly greater IMT values compared with C allele homozygotes [geometric mean (interquartile range) 601 (543-665) vs. 590 (537-647) μm, P = 0.021]. This relationship became stronger after correcting for key covariates, including plasma adiponectin levels (P = 0.011). Conclusion: Variation within the ADIPOQ gene promoter is directly associated with carotid IMT in healthy subjects and is independent of circulating adiponectin levels.

KW - Adiponectin

KW - ADIPOQ gene

KW - Carotid intima media thickness

KW - Genetics

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U2 - 10.1093/eurheartj/ehm526

DO - 10.1093/eurheartj/ehm526

M3 - Article

VL - 29

SP - 386

EP - 393

JO - European Heart Journal

JF - European Heart Journal

SN - 0195-668X

IS - 3

ER -