Variation in world wide incidence of amyotrophic lateral sclerosis: A meta-analysis

Benoît Marin, Farid Boumé diene, Giancarlo Logroscino, Philippe Couratier, Marie Claude Babron, Anne Louise Leutenegger, Massimilano Copetti, Pierre Marie Preux, Ettore Beghi

Research output: Contribution to journalArticlepeer-review


Background: To assess the worldwide variation of amyotrophic lateral sclerosis (ALS) incidence, we performed a systematic review and meta-analysis of population-based data published to date. Methods: We reviewed Medline and Embase up to June 2015 and included all populationbased studies of newly diagnosed ALS cases, using multiple sources for case ascertainment. ALS crude and standardized incidence (on age and sex using the US 2010 population) were calculated. Random effect meta-analysis and meta-regression were performed using the subcontinent as the main study level covariate. Sources of heterogeneity related to the characteristics of the study population and the study methodology were investigated. Results: Among 3216 records, 44 studies were selected, covering 45 geographical areas in 11 sub-continents. A total of 13 146 ALS cases and 825 million person-years of followup (PYFU) were co-nsidered. The overall pooled worldwide crude ALS incidence was at 1.75 (1.55-1.96)/100 000 PYFU; 1.68 (1.50-1.85)/100 000 PYFU after standardization. Heterogeneity was identified in ALS standardized incidence between North Europe [1.89 (1.46-2.32)/100 000 PYFU] and East Asia [0.83 (0.42-1.24)/100 000 PYFU, China and Japan P = 0.001] or South Asia [0.73 (0.58-0.89)/100 000/PYFU Iran, P = 0.02]. Conversely, homogeneous rates have been reported in populations from Europe, North America and New Zealand [pooled ALS standardized incidence of 1.81 (1.66-1.97)/100 000 PYFU for those areas]. Conclusion: This review confirms a heterogeneous distribution worldwide of ALS, and sets the scene to sustain a collaborative study involving a wide international consortium to investigate the link between ancestry, environment and ALS incidence.

Original languageEnglish
Pages (from-to)57-74
Number of pages18
JournalInternational Journal of Epidemiology
Issue number1
Publication statusPublished - Feb 1 2017


  • Amyotrophic lateral sclerosis
  • Epidemiology
  • Ethnic groups
  • Incidence

ASJC Scopus subject areas

  • Epidemiology


Dive into the research topics of 'Variation in world wide incidence of amyotrophic lateral sclerosis: A meta-analysis'. Together they form a unique fingerprint.

Cite this