Variation of B-type natriuretic peptide concentrations and intrauterine growth restriction: Mother, fetus and newborn

Francesca Garofoli, S. Mannarino, L. Montanari, R. Cerbo, C. Tzialla, I. Mazzucchelli, M. Angelini, A. C. Codazzi, M. E. Mongini, P. Manzoni, C. Tinelli, A. Spinillo, M. Stronati

Research output: Contribution to journalArticle

Abstract

To evaluate maternal, fetal, neonatal B-type natriuretic peptide (BNP) concentrations related to Intra Uterine Growth Restriction (IUGR). BNP concentrations in 43 IUGR and 35 healthy, Appropriate for Gestational Age (AGA) infants/paired mothers have been compared, from delivery/birth to first month of life. Maternal and IUGR cord BNP concentrations were coupled to fetal ultrasonography. Neonatal echocardiography was performed too. On delivery BNP was higher in all IUGR mothers, suffering or not from gestational hypertension, than in AGA (median 37.14 vs 11.1 pg/ml p=0.002). Maternal BNP was not associated to cord/neonatal BNP or fetal ultrasonographic parameters. Cord BNP was higher in IUGR than AGA newborns (median 23.9 vs 11.4 pg/ml p=0.0007) independently of gestational age, while varied with amniotic fluid (p=0.0044) and umbilical artery flowmetry (p=0.0121). Earlier drop of BNP on day 3 was reported in IUGR neonates (p=0.0001). Ventricular mass change/body weight varied positively in AGA newborns (p

Original languageEnglish
Pages (from-to)733-739
Number of pages7
JournalJournal of Biological Regulators and Homeostatic Agents
Volume26
Issue number4
Publication statusPublished - Oct 2012

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Keywords

  • BNP
  • IUGR
  • Newborn infant

ASJC Scopus subject areas

  • Oncology
  • Endocrinology, Diabetes and Metabolism
  • Physiology (medical)
  • Immunology and Allergy
  • Immunology
  • Endocrinology
  • Physiology
  • Cancer Research

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