Variations in multiple birth rates and impact on perinatal outcomes in Europe

Anna Heino, Mika Gissler, Ashna D. Hindori-Mohangoo, Béatrice Blondel, Kari Klungsøyr, Ivan Verdenik, Ewa Mierzejewska, Petr Velebil, Helga Sól Ólafsdóttir, Alison Macfarlane, Jennifer Zeitlin, Gerald Haidinger, Sophie Alexander, Pavlos Pavlou, Laust Mortensen, Luule Sakkeus, Nicholas Lack, Aris Antsaklis, Istvan Berbik, Sheelagh BonhamMarina Cuttini, Janis Misins, Jone Jaselioniene, Yolande Wagener, Miriam Gatt, Jan Nijhuis, Karin Van Der Pal, Kari Klungsoyr, Katarzyna Szamotulska, Henrique Barros, Mihai Horga, Jan Cap, Natasa Tul Mandić, Francisco Bolúmar, Karin Gottvall, Sylvie Berrut, Jeannette Klimont, Wei Hong Zhang, Michèle Dramaix-Wilmet, Mélissa Van Humbeeck, Charlotte Leroy, Anne Frédérique Minsart, Virginie Van Leeuw, Evelyne Martens, Myriam De Spiegelaere, Freddy Verkruyssen, Michel Willems, Willem Aelvoet, Jean Tafforeau, Francoise Renard, Denise Walckiers, Deborah Cuignet, Philippe Demoulin, Heidi Cloots, Erik Hendrickx, Anne Kongs, Despina Stylianou, Theopisti Kyprianou, Nicos Skordes, Jens Langhoff Roos, Anne Marie Nybo Anderson, Laust Hvas Mortensen, Annukka Ritvanen, Marie Hélène Bouvier Colle, Anne Ego, Grégoire Rey, Guenther Heller, Anton Scharl, Peter Drakakis, Ragnheidur I. Bjarnadottir, Hildur Hardardóttir, Brynja Ragnarsdóttir, Vigdís Stefánsdóttir, Sigrídur Haraldsdóttir, Aisling Mulligan, Cristina Tamburini, Rosaria Boldrini, Sabrina Prati, Marzia Loghi, Cinzia Castagnaro, Stefano Marchetti, Alessandra Burgio, Monica Da Frè, Irisa Zile, Jelena Isakova, Rita Gaidelyte, Jone Jaselione, Audrey Billy, Aline Touvrey-Lecomte, Karin Van Der, Pal De Bruin, Peter Achterberg, Chantal Hukkelhoven, Ger De Winter, Anita Ravelli, Greta Rijninks-Van Driel, Pieter Tamminga, Martin Groesz, Patty Elferink-Stinkens, Arild Osen, Marta Ebbing, Sofia Correia, Alexandra Cucu, Živa Novak-Antolič, Mireia Jane, Maria Jose Vidal, Carmen Barona, Rosa Mas, Adela Recio Alcaide, Ellen Lundqvist, Claudia König, Monika Schmid, Nirupa Dattani, Jim Chalmers, Kirsten Monteath, Marie Climson, Leslie Marr, Rod Gibson, Gwyneth Thomas, Rhian Osborne, Russell Brown, David Sweet, Joanne Evans, Sinead Magill, Adele Graham, Heather Reid, Terry Falconer, Karen McConnell, Neil McComb

Research output: Contribution to journalArticle

Abstract

Objective: Infants from multiple pregnancies have higher rates of preterm birth, stillbirth and neonatal death and differences in multiple birth rates (MBR) exist between countries. We aimed to describe differences in MBR in Europe and to investigate the impact of these differences on adverse perinatal outcomes at a population level. Methods: We used national aggregate birth data on multiple pregnancies, maternal age, gestational age (GA), stillbirth and neonatal death collected in the Euro-Peristat project (29 countries in 2010, N = 5 074 643 births). We also used European Society of Human Reproduction and Embryology (ESHRE) data on assisted conception and single embryo transfer (SET). The impact of MBR on outcomes was studied using meta-analysis techniques with randomeffects models to derive pooled risk ratios (pRR) overall and for four groups of country defined by their MBR. We computed population attributable risks (PAR) for these groups. Results: In 2010, the average MBR was 16.8 per 1000 women giving birth, ranging from 9.1 (Romania) to 26.5 (Cyprus). Compared to singletons, multiples had a nine-fold increased risk (pRR 9.4, 95% Cl 9.1-9.8) of preterm birth (

Original languageEnglish
Article numbere0149252
JournalPLoS One
Volume11
Issue number3
DOIs
Publication statusPublished - Mar 1 2016

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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    Heino, A., Gissler, M., Hindori-Mohangoo, A. D., Blondel, B., Klungsøyr, K., Verdenik, I., Mierzejewska, E., Velebil, P., Ólafsdóttir, H. S., Macfarlane, A., Zeitlin, J., Haidinger, G., Alexander, S., Pavlou, P., Mortensen, L., Sakkeus, L., Lack, N., Antsaklis, A., Berbik, I., ... McComb, N. (2016). Variations in multiple birth rates and impact on perinatal outcomes in Europe. PLoS One, 11(3), [e0149252]. https://doi.org/10.1371/journal.pone.0149252