Abstract
An inverse relationship between age and human papillomavirus (HPV) prevalence has been reported in many developed countries, but information on this relationship is scarce in many other parts of the world. We carried out a cross-sectional study of sexually active women from the general population of 15 areas in 4 continents. Similar standardised protocols for women's enrolment, cervical specimen collection and PCR-based assays for HPV testing were used. HPV prevalence in different age groups was compared by study area. 18,498 women aged 15-74 years were included. Age-standardised HPV prevalence varied more than 10-fold between populations, as did the shape of age-specific curves. HPV prevalence peaked below age 25 or 35, and declined with age in Italy, the Netherlands, Spain, Argentina, Korea and in Lampang, Thailand and Ho Chi Minh, Vietnam. This was not the case in Songkla, Thailand nor Hanoi, Vietnam, where HPV prevalence was low in all age groups. In Chile, Colombia and Mexico, a second peak of HPV prevalence was detected among older women. In the poorest study areas in Asia (Shanxi, China and Dindigul, India), and in Nigeria, HPV prevalence was high across all age groups. The substantial differences observed in age-specific curves of HPV prevalence between populations may have a variety of explanations. These differences, however, underline that great caution should be used in inferring the natural history of HPV from age-specific prevalences.
| Original language | English |
|---|---|
| Pages (from-to) | 2677-2684 |
| Number of pages | 8 |
| Journal | International Journal of Cancer |
| Volume | 119 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Dec 1 2006 |
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Keywords
- Age-specific curves
- Human papillomavirus
- Prevalence
- Sexual habits
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Variations in the age-specific curves of human papillomavirus prevalence in women worldwide. / Franceschi, Silvia; Herrero, Rolando; Clifford, Gary M.; Snijders, Peter J F; Arslan, Annie; Anh, Pham Thi Hoang; Bosch, F. Xavier; Ferreccio, Catterina; Hieu, Nguyen Trong; Lazcano-Ponce, Eduardo; Matos, Elena; Molano, Monica; Qiao, You Lin; Rajkumar, Raj; Ronco, Guglielmo; De Sanjosé, Silvia; Shin, Hai Rim; Sukvirach, Sukhon; Thomas, Jaiye O.; Meijer, Chris J L M; Munoz, Nubia; Prince, Miguel Angel; Herrera, Lily; Loria, Dora; Luzoro, Amaranta; Ojeda, José Manuel; Prado, Rodrigo; Huang, Ruide; Shao, Shuli; Posso, Hector; Ronderos, Margarita; Dai, Min; Plummer, Martyn; Smith, Jennifer S.; Vaccarella, Salvatore; Ghisetti, Valeria; Gillio-Tos, Anna; Gallus, Silvano; Segnan, Nereo; Lee, Duk Hee; Hernández-Avila, Mauricio; Omigbodun, Akinyinka; Ojemakinde, Kunle; Font, Rebecca; Deechaisate, Apichai; Kesararat, Vitaya; Tunsakul, Sirirat; Yingseri, Pipat; Jacobs, Marcel.
In: International Journal of Cancer, Vol. 119, No. 11, 01.12.2006, p. 2677-2684.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Variations in the age-specific curves of human papillomavirus prevalence in women worldwide
AU - Franceschi, Silvia
AU - Herrero, Rolando
AU - Clifford, Gary M.
AU - Snijders, Peter J F
AU - Arslan, Annie
AU - Anh, Pham Thi Hoang
AU - Bosch, F. Xavier
AU - Ferreccio, Catterina
AU - Hieu, Nguyen Trong
AU - Lazcano-Ponce, Eduardo
AU - Matos, Elena
AU - Molano, Monica
AU - Qiao, You Lin
AU - Rajkumar, Raj
AU - Ronco, Guglielmo
AU - De Sanjosé, Silvia
AU - Shin, Hai Rim
AU - Sukvirach, Sukhon
AU - Thomas, Jaiye O.
AU - Meijer, Chris J L M
AU - Munoz, Nubia
AU - Prince, Miguel Angel
AU - Herrera, Lily
AU - Loria, Dora
AU - Luzoro, Amaranta
AU - Ojeda, José Manuel
AU - Prado, Rodrigo
AU - Huang, Ruide
AU - Shao, Shuli
AU - Posso, Hector
AU - Ronderos, Margarita
AU - Dai, Min
AU - Plummer, Martyn
AU - Smith, Jennifer S.
AU - Vaccarella, Salvatore
AU - Ghisetti, Valeria
AU - Gillio-Tos, Anna
AU - Gallus, Silvano
AU - Segnan, Nereo
AU - Lee, Duk Hee
AU - Hernández-Avila, Mauricio
AU - Omigbodun, Akinyinka
AU - Ojemakinde, Kunle
AU - Font, Rebecca
AU - Deechaisate, Apichai
AU - Kesararat, Vitaya
AU - Tunsakul, Sirirat
AU - Yingseri, Pipat
AU - Jacobs, Marcel
PY - 2006/12/1
Y1 - 2006/12/1
N2 - An inverse relationship between age and human papillomavirus (HPV) prevalence has been reported in many developed countries, but information on this relationship is scarce in many other parts of the world. We carried out a cross-sectional study of sexually active women from the general population of 15 areas in 4 continents. Similar standardised protocols for women's enrolment, cervical specimen collection and PCR-based assays for HPV testing were used. HPV prevalence in different age groups was compared by study area. 18,498 women aged 15-74 years were included. Age-standardised HPV prevalence varied more than 10-fold between populations, as did the shape of age-specific curves. HPV prevalence peaked below age 25 or 35, and declined with age in Italy, the Netherlands, Spain, Argentina, Korea and in Lampang, Thailand and Ho Chi Minh, Vietnam. This was not the case in Songkla, Thailand nor Hanoi, Vietnam, where HPV prevalence was low in all age groups. In Chile, Colombia and Mexico, a second peak of HPV prevalence was detected among older women. In the poorest study areas in Asia (Shanxi, China and Dindigul, India), and in Nigeria, HPV prevalence was high across all age groups. The substantial differences observed in age-specific curves of HPV prevalence between populations may have a variety of explanations. These differences, however, underline that great caution should be used in inferring the natural history of HPV from age-specific prevalences.
AB - An inverse relationship between age and human papillomavirus (HPV) prevalence has been reported in many developed countries, but information on this relationship is scarce in many other parts of the world. We carried out a cross-sectional study of sexually active women from the general population of 15 areas in 4 continents. Similar standardised protocols for women's enrolment, cervical specimen collection and PCR-based assays for HPV testing were used. HPV prevalence in different age groups was compared by study area. 18,498 women aged 15-74 years were included. Age-standardised HPV prevalence varied more than 10-fold between populations, as did the shape of age-specific curves. HPV prevalence peaked below age 25 or 35, and declined with age in Italy, the Netherlands, Spain, Argentina, Korea and in Lampang, Thailand and Ho Chi Minh, Vietnam. This was not the case in Songkla, Thailand nor Hanoi, Vietnam, where HPV prevalence was low in all age groups. In Chile, Colombia and Mexico, a second peak of HPV prevalence was detected among older women. In the poorest study areas in Asia (Shanxi, China and Dindigul, India), and in Nigeria, HPV prevalence was high across all age groups. The substantial differences observed in age-specific curves of HPV prevalence between populations may have a variety of explanations. These differences, however, underline that great caution should be used in inferring the natural history of HPV from age-specific prevalences.
KW - Age-specific curves
KW - Human papillomavirus
KW - Prevalence
KW - Sexual habits
UR - http://www.scopus.com/inward/record.url?scp=33750618693&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33750618693&partnerID=8YFLogxK
U2 - 10.1002/ijc.22241
DO - 10.1002/ijc.22241
M3 - Article
C2 - 16991121
AN - SCOPUS:33750618693
VL - 119
SP - 2677
EP - 2684
JO - International Journal of Cancer
JF - International Journal of Cancer
SN - 0020-7136
IS - 11
ER -