Variations of proline-rich kinase Pyk2 expression correlate with prostate cancer progression

Rosita Stanzione, Antonietta Picascia, Paolo Chieffi, Ciro Imbimbo, Alessandro Palmieri, Vincenzo Mirone, Stefania Staibano, Renato Franco, Gaetano De Rosa, Joseph Schlessinger, Donatella Tramontano

Research output: Contribution to journalArticlepeer-review


Proline-rich kinase 2 (Pyk2), also known as CAKβ (cell adhesion kinase β), is a cytoplasmic tyrosine kinase that is structurally related to focal adhesion kinase. Pyk2 is expressed in different cell types including brain cells, fibroblasts, platelets, and other hemopoietic cells. Pyk2 is rapidly tyrosine phosphorylated in response to diverse extracellular signals acting via different post receptor pathways. We have investigated whether this protein kinase is functionally expressed in normal and neoplastic prostate tissues. In this study, we demonstrate that Pyk2 is expressed only in normal epithelial prostate tissue and in benign prostatic hyperplasia, whereas its expression progressively declines with an increasing grade of malignancy of prostate cancer.

Original languageEnglish
Pages (from-to)51-59
Number of pages9
JournalLaboratory Investigation
Issue number1
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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