TY - JOUR
T1 - Variations of proline-rich kinase Pyk2 expression correlate with prostate cancer progression
AU - Stanzione, Rosita
AU - Picascia, Antonietta
AU - Chieffi, Paolo
AU - Imbimbo, Ciro
AU - Palmieri, Alessandro
AU - Mirone, Vincenzo
AU - Staibano, Stefania
AU - Franco, Renato
AU - De Rosa, Gaetano
AU - Schlessinger, Joseph
AU - Tramontano, Donatella
PY - 2001
Y1 - 2001
N2 - Proline-rich kinase 2 (Pyk2), also known as CAKβ (cell adhesion kinase β), is a cytoplasmic tyrosine kinase that is structurally related to focal adhesion kinase. Pyk2 is expressed in different cell types including brain cells, fibroblasts, platelets, and other hemopoietic cells. Pyk2 is rapidly tyrosine phosphorylated in response to diverse extracellular signals acting via different post receptor pathways. We have investigated whether this protein kinase is functionally expressed in normal and neoplastic prostate tissues. In this study, we demonstrate that Pyk2 is expressed only in normal epithelial prostate tissue and in benign prostatic hyperplasia, whereas its expression progressively declines with an increasing grade of malignancy of prostate cancer.
AB - Proline-rich kinase 2 (Pyk2), also known as CAKβ (cell adhesion kinase β), is a cytoplasmic tyrosine kinase that is structurally related to focal adhesion kinase. Pyk2 is expressed in different cell types including brain cells, fibroblasts, platelets, and other hemopoietic cells. Pyk2 is rapidly tyrosine phosphorylated in response to diverse extracellular signals acting via different post receptor pathways. We have investigated whether this protein kinase is functionally expressed in normal and neoplastic prostate tissues. In this study, we demonstrate that Pyk2 is expressed only in normal epithelial prostate tissue and in benign prostatic hyperplasia, whereas its expression progressively declines with an increasing grade of malignancy of prostate cancer.
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M3 - Article
C2 - 11204274
AN - SCOPUS:0035137271
VL - 81
SP - 51
EP - 59
JO - Laboratory Investigation
JF - Laboratory Investigation
SN - 0023-6837
IS - 1
ER -