TY - JOUR
T1 - Varied functions of immune checkpoints during cancer metastasis.
AU - Safarzadeh, Ali
AU - Alizadeh, Mohsen
AU - Beyranvand, Fatemeh
AU - Falavand Jozaaee, Reza
AU - Hajiasgharzadeh, Khalil
AU - Baghbanzadeh, Amir
AU - Derakhshani, Afshin
AU - Argentiero, Antonella
AU - Baradaran, Behzad
AU - Silvestris, Nicola
N1 - Publisher Copyright:
© 2020, The Author(s).
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2021/3
Y1 - 2021/3
N2 - Immune checkpoints comprise diverse receptors and ligands including costimulatory and inhibitory molecules, which play monumental roles in regulating the immune system. Immune checkpoints retain key potentials in maintaining the immune system homeostasis and hindering the malignancy development and autoimmunity. The expression of inhibitory immune checkpoints delineates an increase in a plethora of metastatic tumors and the inhibition of these immune checkpoints can be followed by promising results. On the other hand, the stimulation of costimulatory immune checkpoints can restrain the metastasis originating from diverse tumors. From the review above, key findings emerged regarding potential functions of inhibitory and costimulatory immune checkpoints targeting the metastatic cascade and point towards novel potential Achilles’ heels of cancer that might be exploited therapeutically in the future.
AB - Immune checkpoints comprise diverse receptors and ligands including costimulatory and inhibitory molecules, which play monumental roles in regulating the immune system. Immune checkpoints retain key potentials in maintaining the immune system homeostasis and hindering the malignancy development and autoimmunity. The expression of inhibitory immune checkpoints delineates an increase in a plethora of metastatic tumors and the inhibition of these immune checkpoints can be followed by promising results. On the other hand, the stimulation of costimulatory immune checkpoints can restrain the metastasis originating from diverse tumors. From the review above, key findings emerged regarding potential functions of inhibitory and costimulatory immune checkpoints targeting the metastatic cascade and point towards novel potential Achilles’ heels of cancer that might be exploited therapeutically in the future.
KW - Immune checkpoints
KW - Immune system
KW - Metastasis
KW - Tumor
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U2 - 10.1007/s00262-020-02717-2
DO - 10.1007/s00262-020-02717-2
M3 - Review article
AN - SCOPUS:85090459919
VL - 70
SP - 569
EP - 588
JO - Cancer Immunology and Immunotherapy
JF - Cancer Immunology and Immunotherapy
SN - 0340-7004
IS - 3
ER -