Varieties of progressive non-fluent aphasia

S. F. Cappa, D. Perani, C. Messa, A. Miozzo, F. Fazio

Research output: Contribution to journalArticlepeer-review


We report four patients with progressive aphasia of the non-fluent type as the presenting clinical manifestation. The patients were included in a longitudinal study of focal progressive neuropsychological syndromes, and were periodically submitted to neuropsychological evaluations and neuroimaging studies (TC, MRI, SPET or PET). The pattern of neuropsychological impairment was in good agreement with the results of functional imaging studies, which indicated involvement of the anterior regions of the left hemisphere. The evolution of the clinical picture was extremely heterogeneous in the four patients, ranging from a relatively stable picture of transcortical motor aphasia to a severe progressive frontal lobe syndrome. Progressive non-fluent aphasia appears to be a reliable clinical marker of the localization of the pathological process; whether this is related to specific neuropathological conditions, such as Pick's disease, remains for the moment a matter of speculation.

Original languageEnglish
Pages (from-to)243-248
Number of pages6
JournalAnnals of the New York Academy of Sciences
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


Dive into the research topics of 'Varieties of progressive non-fluent aphasia'. Together they form a unique fingerprint.

Cite this