Variety in vegetable and fruit consumption and risk of bladder cancer in the European Prospective Investigation into Cancer and Nutrition

Frederike L. Büchner, H. Bas Bueno-De-Mesquita, Martine M. Ros, Ellen Kampman, Lars Egevad, Kim Overvad, Anne Tjãnneland, Nina Roswall, Franãoise Clavel-Chapelon, Marie Christine Boutron-Ruault, Marina Touillaud, Rudolf Kaaks, Jenny Chang-Claude, Heiner Boeing, Steffen Weikert, Antonia Trichopoulou, Ada Naska, Vicky Benetou, Domenico Palli, Sabina SieriPaolo Vineis, Rosario Tumino, Salvatore Panico, Fränzel J B Van Duijnhoven, Petra H M Peeters, Carla H. Van Gils, Eiliv Lund, Inger T. Gram, Maria José Sánchez, Paula Jakszyn, Nerea Larrañaga, Eva Ardanaz, Carmen Navarro, Laudina Rodríguez, Jonas Manjer, Roy Ehrnström, Göran Hallmans, Börje Ljungberg, Tim J. Key, Naomi E. Allen, Kay Tee Khaw, Nicholas Wareham, Nadia Slimani, Mazda Jenab, Paolo Boffetta, Lambertus A L M Kiemeney, Elio Riboli

Research output: Contribution to journalArticle

Abstract

Recent research does not show an association between fruit and vegetable consumption and bladder cancer risk. None of these studies investigated variety in fruit and vegetable consumption, which may capture different aspects of consumption. We investigated whether a varied consumption of vegetables and fruits is associated with bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Detailed data on food consumption and complete follow-up for cancer incidence were available for 452,185 participants, who were recruited from ten European countries. After a mean follow-up of 8.7 years, 874 participants were diagnosed with bladder cancer. Diet diversity scores (DDSs) were used to quantify the variety in fruit and vegetable consumption. Multivariable Cox proportional hazard models were used to assess the effect of the DDSs on bladder cancer risk. There was no evidence of a statistically significant association between bladder cancer risk and any of the DDSs when these scores were considered as continuous covariates. However, the hazard ratio (HR) for the highest tertile of the DDS for combined fruit and vegetable consumption was marginally significant compared to the lowest (HR = 1.30, 95% confidence interval: 1.00-1.69, p-trend = 0.05). In EPIC, there is no clear association between a varied fruit and vegetable consumption and bladder cancer risk. This finding provides further evidence for the absence of any strong association between fruit and vegetable consumption as measured by a food frequency questionnaire and bladder cancer risk.

Original languageEnglish
Pages (from-to)2971-2979
Number of pages9
JournalInternational Journal of Cancer
Volume128
Issue number12
DOIs
Publication statusPublished - Jun 15 2011

Keywords

  • bladder cancer
  • DDS
  • EPIC
  • fruit
  • vegetables

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Büchner, F. L., Bueno-De-Mesquita, H. B., Ros, M. M., Kampman, E., Egevad, L., Overvad, K., Tjãnneland, A., Roswall, N., Clavel-Chapelon, F., Boutron-Ruault, M. C., Touillaud, M., Kaaks, R., Chang-Claude, J., Boeing, H., Weikert, S., Trichopoulou, A., Naska, A., Benetou, V., Palli, D., ... Riboli, E. (2011). Variety in vegetable and fruit consumption and risk of bladder cancer in the European Prospective Investigation into Cancer and Nutrition. International Journal of Cancer, 128(12), 2971-2979. https://doi.org/10.1002/ijc.25636