TY - JOUR
T1 - Vascular ageing
T2 - The role of oxidative stress
AU - Puca, Annibale Alessandro
AU - Carrizzo, Albino
AU - Villa, Francesco
AU - Ferrario, Anna
AU - Casaburo, Manuel
AU - MacIa̧g, Anna
AU - Vecchione, Carmine
PY - 2013/3
Y1 - 2013/3
N2 - Vascular ageing can be envisioned as the consequence of the accumulation of reactive oxygen species (ROS) associated with generalized endothelial dysfunction. Oxidative stress arises when the balance between production and removal of ROS favours the pro-oxidation arm. Therefore, ROS have been traditionally considered to be only a toxic by-product of aerobic metabolism. However, it has become apparent that ROS might control many different physiological processes, such as stress response, pathogen defence and systemic signalling. This has lead to the hypothesis that a certain level of ROS is needed physiologically, so much so that an overly increased antioxidant potential might be deleterious for health. Recent evidence has strengthened this notion by correlating cellular response with oxidants and the mechanisms that regulate longevity. Here, we overview current literature on this topic and we will try to convince the reader of the importance of balanced oxidative stress for vascular integrity and healthy ageing.
AB - Vascular ageing can be envisioned as the consequence of the accumulation of reactive oxygen species (ROS) associated with generalized endothelial dysfunction. Oxidative stress arises when the balance between production and removal of ROS favours the pro-oxidation arm. Therefore, ROS have been traditionally considered to be only a toxic by-product of aerobic metabolism. However, it has become apparent that ROS might control many different physiological processes, such as stress response, pathogen defence and systemic signalling. This has lead to the hypothesis that a certain level of ROS is needed physiologically, so much so that an overly increased antioxidant potential might be deleterious for health. Recent evidence has strengthened this notion by correlating cellular response with oxidants and the mechanisms that regulate longevity. Here, we overview current literature on this topic and we will try to convince the reader of the importance of balanced oxidative stress for vascular integrity and healthy ageing.
KW - Ageing
KW - Longevity
KW - Oxidative stress
KW - Vascular integrity
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UR - http://www.scopus.com/inward/citedby.url?scp=84872508264&partnerID=8YFLogxK
U2 - 10.1016/j.biocel.2012.12.024
DO - 10.1016/j.biocel.2012.12.024
M3 - Article
C2 - 23305730
AN - SCOPUS:84872508264
VL - 45
SP - 556
EP - 559
JO - International Journal of Biochemistry and Cell Biology
JF - International Journal of Biochemistry and Cell Biology
SN - 1357-2725
IS - 3
ER -