Vascular alterations in apolipoprotein A-I amyloidosis (Leu75Pro). A case-control study

Maria Lorenza Muiesan, Massimo Salvetti, Anna Paini, Claudia Agabiti Rosei, Giulia Rubagotti, Alessandro Negrinelli, Gina Gregorini, Giovanni Cancarini, Laura Calabresi, Guido Franceschini, Laura Obici, Stefano Perlini, Giampaolo Merlini, Enrico Agabiti Rosei

Research output: Contribution to journalArticle

Abstract

Background: Among hereditary amyloidoses, apolipoprotein A-I (APO A-I) amyloidosis (Leu75Pro) is a rare, autosomal dominant condition in which renal, hepatic, and testicular involvement has been demonstrated. Objective: To investigate vascular structural as well as functional alterations. Methods: In 131 carriers of the amyloidogenic Leu75Pro APO A-I mutation (mean age 52 + 16 years, 56 women) and in 131 subjects matched for age, sex, body mass index and clinic blood pressure (BP), arterial stiffness (pulse wave velocity, PWV) and carotid intima-media thickness (IMT) were measured. Results: By definition no differences for age, sex, body mass index, and BP were observed. Meanmax IMT (Mmax-IMT) in the common (CC), bifurcation (BIF) and internal (ICA) carotid artery were comparable in the two groups. After adjustment for high-density lipoprotein cholesterol and renal function differences between the two groups, a lower meanmax-IMT was observed in APO A-I Leu75Pro mutation carriers than in controls (CC Mmax-IMT 0.87 ± 0.21 versus 0.93 ± 0.2 mm, p = 0.07; BIF Mmax-IMT 1.19 ± 0.48 versus 1.36 ± 0.46 mm, p = 0.025; ICA Mmax-IMT 0.9 ± 0.37 versus 1.02 ± 0.35 mm, p = 0.028). On the other hand, aortic stiffness was significantly greater in patients with APO A-I amyloidosis than controls (PWV 11.5 ± 2.9 and 10.7 ± 2.3 m/s, p <0.05), even after adjusting for confounders. Conclusions: In carriers of the amyloidogenic Leu75Pro APO A-I mutation, a significant increase in arterial stiffness is observed; on the contrary, carotid artery IMT is comparable to that of control subjects. These results may add significant information to the clinical features of this rare genetic disorder.

Original languageEnglish
Pages (from-to)187-193
Number of pages7
JournalAmyloid
Volume22
Issue number3
DOIs
Publication statusPublished - Jul 3 2015

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Apolipoprotein A-I
Amyloidosis
Blood Vessels
Case-Control Studies
Vascular Stiffness
Carotid Intima-Media Thickness
Pulse Wave Analysis
Mutation
Body Mass Index
Familial Amyloidosis
Blood Pressure
Kidney
Inborn Genetic Diseases
Internal Carotid Artery
Carotid Arteries
Sex Characteristics
HDL Cholesterol
Liver

Keywords

  • Aortic stiffness
  • apolipoprotein A-I
  • chronic kidney disease
  • hereditary amyloidosis
  • intima-media thickness

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Muiesan, M. L., Salvetti, M., Paini, A., Agabiti Rosei, C., Rubagotti, G., Negrinelli, A., ... Rosei, E. A. (2015). Vascular alterations in apolipoprotein A-I amyloidosis (Leu75Pro). A case-control study. Amyloid, 22(3), 187-193. https://doi.org/10.3109/13506129.2015.1066771

Vascular alterations in apolipoprotein A-I amyloidosis (Leu75Pro). A case-control study. / Muiesan, Maria Lorenza; Salvetti, Massimo; Paini, Anna; Agabiti Rosei, Claudia; Rubagotti, Giulia; Negrinelli, Alessandro; Gregorini, Gina; Cancarini, Giovanni; Calabresi, Laura; Franceschini, Guido; Obici, Laura; Perlini, Stefano; Merlini, Giampaolo; Rosei, Enrico Agabiti.

In: Amyloid, Vol. 22, No. 3, 03.07.2015, p. 187-193.

Research output: Contribution to journalArticle

Muiesan, ML, Salvetti, M, Paini, A, Agabiti Rosei, C, Rubagotti, G, Negrinelli, A, Gregorini, G, Cancarini, G, Calabresi, L, Franceschini, G, Obici, L, Perlini, S, Merlini, G & Rosei, EA 2015, 'Vascular alterations in apolipoprotein A-I amyloidosis (Leu75Pro). A case-control study', Amyloid, vol. 22, no. 3, pp. 187-193. https://doi.org/10.3109/13506129.2015.1066771
Muiesan ML, Salvetti M, Paini A, Agabiti Rosei C, Rubagotti G, Negrinelli A et al. Vascular alterations in apolipoprotein A-I amyloidosis (Leu75Pro). A case-control study. Amyloid. 2015 Jul 3;22(3):187-193. https://doi.org/10.3109/13506129.2015.1066771
Muiesan, Maria Lorenza ; Salvetti, Massimo ; Paini, Anna ; Agabiti Rosei, Claudia ; Rubagotti, Giulia ; Negrinelli, Alessandro ; Gregorini, Gina ; Cancarini, Giovanni ; Calabresi, Laura ; Franceschini, Guido ; Obici, Laura ; Perlini, Stefano ; Merlini, Giampaolo ; Rosei, Enrico Agabiti. / Vascular alterations in apolipoprotein A-I amyloidosis (Leu75Pro). A case-control study. In: Amyloid. 2015 ; Vol. 22, No. 3. pp. 187-193.
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AU - Rubagotti, Giulia

AU - Negrinelli, Alessandro

AU - Gregorini, Gina

AU - Cancarini, Giovanni

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AU - Franceschini, Guido

AU - Obici, Laura

AU - Perlini, Stefano

AU - Merlini, Giampaolo

AU - Rosei, Enrico Agabiti

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