Vascular endothelial growth factor and its receptors in multiple myeloma

R. Ria, A. M. Roccaro, F. Merchionne, A. Vacca, F. Dammacco, D. Ribatti

Research output: Contribution to journalArticlepeer-review


Multiple myeloma (MM) progresses from an avascular to a vascular phase (active MM) accompanied by a significant increase in microvessel density in the bone marrow. This article summarizes the literature concerning the specific role played by vascular endothelial growth factor (VEGF) in this process. Recent applications of antiangiogenic agents that interfere with VEGF signaling and block MM progression are also described.

Original languageEnglish
Pages (from-to)1961-1966
Number of pages6
Issue number10
Publication statusPublished - Oct 2003


  • Angiogenesis
  • Endothelial cells
  • Multiple myeloma
  • Tumor growth
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Hematology
  • Cancer Research


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