Vascular endothelial growth factor and its receptors in multiple myeloma

R. Ria, A. M. Roccaro, F. Merchionne, A. Vacca, F. Dammacco, D. Ribatti

Research output: Contribution to journalArticlepeer-review

Abstract

Multiple myeloma (MM) progresses from an avascular to a vascular phase (active MM) accompanied by a significant increase in microvessel density in the bone marrow. This article summarizes the literature concerning the specific role played by vascular endothelial growth factor (VEGF) in this process. Recent applications of antiangiogenic agents that interfere with VEGF signaling and block MM progression are also described.

Original languageEnglish
Pages (from-to)1961-1966
Number of pages6
JournalLeukemia
Volume17
Issue number10
DOIs
Publication statusPublished - Oct 2003

Keywords

  • Angiogenesis
  • Endothelial cells
  • Multiple myeloma
  • Tumor growth
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Hematology
  • Cancer Research

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