Vascular endothelial growth factor and vascular endothelial growth factor receptor-2 expression in mdx mouse brain

Beatrice Nico, Patrizia Corsi, Angelo Vacca, Luisa Roncali, Domenico Ribatti

Research output: Contribution to journalArticlepeer-review

Abstract

Recent data have demonstrated that vascular endothelial growth factor (VEGF) is expressed by subsets of neurons, coincident with angiogenesis within its developing cerebral cortex. In this study, with the aim of elucidating the mechanisms of vascular involvement during brain impairment in Duchenne muscular distrophy (DMD), we have correlated the vascular density with VEGF and VEGF receptor-2 (VEGFR-2) expression in the brain cortex of normal and mdx mouse, an animal model with a genetic defect in a region homologous with the human DMD gene. Results showed that in mdx mouse, tissue area occupied by microvessels positive to factor VIII related antigen and VEGFR-2 increased in parallel to the tissue area occupied by neurons positive to VEGF. Our data suggest that increased vascularity in the brain of mdx mouse may be due, at least in part, to proliferation of endothelial cells in response to VEGF secreted by neuronal cells.

Original languageEnglish
Pages (from-to)12-16
Number of pages5
JournalBrain Research
Volume953
Issue number1-2
DOIs
Publication statusPublished - Nov 20 2002

Keywords

  • Angiogenesis
  • Cerebral cortex
  • Duchenne muscular distrophy
  • Endothelial cells
  • VEGF
  • VEGFR-2

ASJC Scopus subject areas

  • Neuroscience(all)

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