Vascular endothelial growth factor blockade elicits a stable metabolic shift in tumor cells: therapeutic implications

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Abstract

The metabolism of tumors differs remarkably from that of normal tissues, but whether this is a stable feature of tumor cells is largely unknown. Recent findings by independent teams indicate that antiangiogenic drugs cause a metabolic shift in tumor cells that is associated with increased malignancy. These results suggest therapy-driven evolutionary dynamics of tumor metabolism that could be therapeutically targeted.

Original languageEnglish
Pages (from-to)e1008307
JournalMolecular & cellular oncology
Volume3
Issue number2
DOIs
Publication statusPublished - Mar 2016

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Vascular Endothelial Growth Factor A
Neoplasms
Therapeutics
Pharmaceutical Preparations

Keywords

  • Journal Article

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title = "Vascular endothelial growth factor blockade elicits a stable metabolic shift in tumor cells: therapeutic implications",
abstract = "The metabolism of tumors differs remarkably from that of normal tissues, but whether this is a stable feature of tumor cells is largely unknown. Recent findings by independent teams indicate that antiangiogenic drugs cause a metabolic shift in tumor cells that is associated with increased malignancy. These results suggest therapy-driven evolutionary dynamics of tumor metabolism that could be therapeutically targeted.",
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