TY - JOUR
T1 - Vascular endothelial growth factor enhances atherosclerotic plaque progression
AU - Celletti, Francesca L.
AU - Waugh, Jacob M.
AU - Amabile, Philippe G.
AU - Brendolan, Andrea
AU - Hilfiker, Paul R.
AU - Dake, Michael D.
PY - 2001
Y1 - 2001
N2 - Vascular endothelial growth factor (VEGF) can promote angiogenesis but may also exert certain effects to alter the rate of atherosclerotic plaque development. To evaluate this potential impact on plaque progression, we treated cholesterol-fed mice doubly deficient in apolipoprotein E/apolipoprotein B100 with low doses of VEGF (2 μg/kg) or albumin. VEGF significantly increased macrophage levels in bone marrow and peripheral blood and increased plaque area 5-,14- and 4-fold compared with controls at weeks 1, 2 and 3, respectively. Plaque macrophage and endothelial cell content also increased disproportionately over controls. In order to confirm that the VEGF-mediated plaque progression was not species-specific, the experiment was repeated in cholesterol-fed rabbits at the three-week timepoint, which showed comparable increases in plaque progression.
AB - Vascular endothelial growth factor (VEGF) can promote angiogenesis but may also exert certain effects to alter the rate of atherosclerotic plaque development. To evaluate this potential impact on plaque progression, we treated cholesterol-fed mice doubly deficient in apolipoprotein E/apolipoprotein B100 with low doses of VEGF (2 μg/kg) or albumin. VEGF significantly increased macrophage levels in bone marrow and peripheral blood and increased plaque area 5-,14- and 4-fold compared with controls at weeks 1, 2 and 3, respectively. Plaque macrophage and endothelial cell content also increased disproportionately over controls. In order to confirm that the VEGF-mediated plaque progression was not species-specific, the experiment was repeated in cholesterol-fed rabbits at the three-week timepoint, which showed comparable increases in plaque progression.
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U2 - 10.1038/86490
DO - 10.1038/86490
M3 - Article
C2 - 11283668
AN - SCOPUS:0035047885
VL - 7
SP - 425
EP - 429
JO - Nature Medicine
JF - Nature Medicine
SN - 1078-8956
IS - 4
ER -