TY - JOUR
T1 - Vascular endothelial growth factor overexpression in myelodysplastic syndrome bone marrow cells
T2 - biological and clinical implications
AU - Invernizzi, Rosangela
AU - Travaglino, Erica
AU - Della Porta, Matteo Giovanni
AU - Malcovati, Luca
AU - Gallì, Anna
AU - Bastia, Raffaella
AU - Ciola, Mariella
AU - Ambaglio, Ilaria
AU - Boveri, Emanuela
AU - Rosti, Vittorio
AU - Cazzola, Mario
PY - 2016/11/29
Y1 - 2016/11/29
N2 - In myelodysplastic syndrome (MDS), vascular endothelial growth factor (VEGF) may have regulatory effects on the hematopoietic system and contribute to disease progression. We analyzed by immunocytochemistry VEGF expression in bone marrow (BM) cells from 188 patients with MDS and 96 non-hemopathic subjects. We also measured VEGF BM plasma levels and in vitro VEGF release. Our aims were to evaluate whether VEGF expression abnormalities were associated with relevant laboratory or clinical findings and their possible prognostic value. In MDS, VEGF expression was higher than in controls (p < .0001) and VEGF release was significantly higher in the low-risk cases. A trend to a positive correlation between VEGF myeloid expression and apoptotic rate was observed. High myeloid VEGF levels were independently associated with longer overall survival (p < .0001) and progression-free survival (p = .0002). Our findings suggest that, in MDS, VEGF production and release may contribute to ineffective hematopoiesis, with a potential prognostic role.
AB - In myelodysplastic syndrome (MDS), vascular endothelial growth factor (VEGF) may have regulatory effects on the hematopoietic system and contribute to disease progression. We analyzed by immunocytochemistry VEGF expression in bone marrow (BM) cells from 188 patients with MDS and 96 non-hemopathic subjects. We also measured VEGF BM plasma levels and in vitro VEGF release. Our aims were to evaluate whether VEGF expression abnormalities were associated with relevant laboratory or clinical findings and their possible prognostic value. In MDS, VEGF expression was higher than in controls (p < .0001) and VEGF release was significantly higher in the low-risk cases. A trend to a positive correlation between VEGF myeloid expression and apoptotic rate was observed. High myeloid VEGF levels were independently associated with longer overall survival (p < .0001) and progression-free survival (p = .0002). Our findings suggest that, in MDS, VEGF production and release may contribute to ineffective hematopoiesis, with a potential prognostic role.
KW - bone marrow
KW - myelodysplastic syndrome
KW - prognosis
KW - Vascular endothelial growth factor
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U2 - 10.1080/10428194.2016.1262030
DO - 10.1080/10428194.2016.1262030
M3 - Article
AN - SCOPUS:84999673389
SP - 1
EP - 10
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
SN - 1042-8194
ER -