Vascular endothelial growth factor (VEGF-A) plasma levels in non-small cell lung cancer: Relationship with coagulation and platelet activation markers

Mario Roselli, Tommaso C. Mineo, Stefania Basili, Sabrina Mariotti, Francesca Martini, Annamaria Bellotti, Vincenzo Ambrogi, Antonella Spila, Roberta D'Alessandro, Pier Paolo Gazzaniga, Fiorella Guadagni, Patrizia Ferroni

Research output: Contribution to journalArticlepeer-review

Abstract

Platelet activation, commonly found in lung cancer patients, may cause the release of angiogenic factors, such as vascular endothelial growth factor (VEGF-A). The present study was designed to investigate whether plasma VEGF-A levels were associated to different stages of non-small cell lung cancer (NSCLC). Moreover, sP-selectin, prothrombin fragment 1+2 (F1+2), thrombin-antithrombin III complex (TATc) and D-dimer levels were measured to test the hypothesis of an involvement of platelet and coagulation activation in tumor angiogenesis. VEGF-A, sP-selectin, F1+2, TATc and D-dimer levels were elevated in 65 patients with NSCLC, particularly in metastatic patients. sP-selectin (p

Original languageEnglish
Pages (from-to)177-184
Number of pages8
JournalThrombosis and Haemostasis
Volume89
Issue number1
Publication statusPublished - Jan 1 2003

Keywords

  • Angiogenesis
  • Lung cancer
  • Soluble P-selectin
  • Thrombin generation
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Hematology

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