Vascular endothelial growth factor (VEGF-A) plasma levels in non-small cell lung cancer: Relationship with coagulation and platelet activation markers

Mario Roselli; Tommaso C. Mineo; Stefania Basili; Sabrina Mariotti; Francesca Martini; Annamaria Bellotti; Vincenzo Ambrogi; Antonella Spila; Roberta D'Alessandro; Pier Paolo Gazzaniga; Fiorella Guadagni; Patrizia Ferroni

Vascular endothelial growth factor (VEGF-A) plasma levels in non-small cell lung cancer: Relationship with coagulation and platelet activation markers

Mario Roselli, Tommaso C. Mineo, Stefania Basili, Sabrina Mariotti, Francesca Martini, Annamaria Bellotti, Vincenzo Ambrogi, Antonella Spila, Roberta D'Alessandro, Pier Paolo Gazzaniga, Fiorella Guadagni, Patrizia Ferroni

Istituto San Raffaele Pisana

Research output: Contribution to journal › Article › peer-review

Abstract

Platelet activation, commonly found in lung cancer patients, may cause the release of angiogenic factors, such as vascular endothelial growth factor (VEGF-A). The present study was designed to investigate whether plasma VEGF-A levels were associated to different stages of non-small cell lung cancer (NSCLC). Moreover, sP-selectin, prothrombin fragment 1+2 (F1+2), thrombin-antithrombin III complex (TATc) and D-dimer levels were measured to test the hypothesis of an involvement of platelet and coagulation activation in tumor angiogenesis. VEGF-A, sP-selectin, F1+2, TATc and D-dimer levels were elevated in 65 patients with NSCLC, particularly in metastatic patients. sP-selectin (p

Original language	English
Pages (from-to)	177-184
Number of pages	8
Journal	Thrombosis and Haemostasis
Volume	89
Issue number	1
Publication status	Published - Jan 1 2003

Keywords

Angiogenesis
Lung cancer
Soluble P-selectin
Thrombin generation
Vascular endothelial growth factor

ASJC Scopus subject areas

Hematology

Cite this

Roselli, M., Mineo, T. C., Basili, S., Mariotti, S., Martini, F., Bellotti, A., Ambrogi, V., Spila, A., D'Alessandro, R., Gazzaniga, P. P., Guadagni, F., & Ferroni, P. (2003). Vascular endothelial growth factor (VEGF-A) plasma levels in non-small cell lung cancer: Relationship with coagulation and platelet activation markers. Thrombosis and Haemostasis, 89(1), 177-184.

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title = "Vascular endothelial growth factor (VEGF-A) plasma levels in non-small cell lung cancer: Relationship with coagulation and platelet activation markers",

abstract = "Platelet activation, commonly found in lung cancer patients, may cause the release of angiogenic factors, such as vascular endothelial growth factor (VEGF-A). The present study was designed to investigate whether plasma VEGF-A levels were associated to different stages of non-small cell lung cancer (NSCLC). Moreover, sP-selectin, prothrombin fragment 1+2 (F1+2), thrombin-antithrombin III complex (TATc) and D-dimer levels were measured to test the hypothesis of an involvement of platelet and coagulation activation in tumor angiogenesis. VEGF-A, sP-selectin, F1+2, TATc and D-dimer levels were elevated in 65 patients with NSCLC, particularly in metastatic patients. sP-selectin (p ",

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author = "Mario Roselli and Mineo, {Tommaso C.} and Stefania Basili and Sabrina Mariotti and Francesca Martini and Annamaria Bellotti and Vincenzo Ambrogi and Antonella Spila and Roberta D'Alessandro and Gazzaniga, {Pier Paolo} and Fiorella Guadagni and Patrizia Ferroni",

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AU - Roselli, Mario

AU - Mineo, Tommaso C.

AU - Basili, Stefania

AU - Mariotti, Sabrina

AU - Martini, Francesca

AU - Bellotti, Annamaria

AU - Ambrogi, Vincenzo

AU - Spila, Antonella

AU - D'Alessandro, Roberta

AU - Gazzaniga, Pier Paolo

AU - Guadagni, Fiorella

AU - Ferroni, Patrizia

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N2 - Platelet activation, commonly found in lung cancer patients, may cause the release of angiogenic factors, such as vascular endothelial growth factor (VEGF-A). The present study was designed to investigate whether plasma VEGF-A levels were associated to different stages of non-small cell lung cancer (NSCLC). Moreover, sP-selectin, prothrombin fragment 1+2 (F1+2), thrombin-antithrombin III complex (TATc) and D-dimer levels were measured to test the hypothesis of an involvement of platelet and coagulation activation in tumor angiogenesis. VEGF-A, sP-selectin, F1+2, TATc and D-dimer levels were elevated in 65 patients with NSCLC, particularly in metastatic patients. sP-selectin (p

AB - Platelet activation, commonly found in lung cancer patients, may cause the release of angiogenic factors, such as vascular endothelial growth factor (VEGF-A). The present study was designed to investigate whether plasma VEGF-A levels were associated to different stages of non-small cell lung cancer (NSCLC). Moreover, sP-selectin, prothrombin fragment 1+2 (F1+2), thrombin-antithrombin III complex (TATc) and D-dimer levels were measured to test the hypothesis of an involvement of platelet and coagulation activation in tumor angiogenesis. VEGF-A, sP-selectin, F1+2, TATc and D-dimer levels were elevated in 65 patients with NSCLC, particularly in metastatic patients. sP-selectin (p

KW - Angiogenesis

KW - Lung cancer

KW - Soluble P-selectin

KW - Thrombin generation

KW - Vascular endothelial growth factor

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Vascular endothelial growth factor (VEGF-A) plasma levels in non-small cell lung cancer: Relationship with coagulation and platelet activation markers

Abstract

Keywords

ASJC Scopus subject areas

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