Vascular growth factors play critical roles in kidney glomeruli

Luigi Gnudi, Sara Benedetti, Adrian S. Woolf, David A. Long

Research output: Contribution to journalArticle

Abstract

Kidney glomeruli ultrafilter blood to generate urine and they are dysfunctional in a variety of kidney diseases. There are two key vascular growth factor families implicated in glomerular biology and function, namely the vascular endothelial growth factors (VEGFs) and the angiopoietins (Angpt). We present examples showing not only how these molecules help generate and maintain healthy glomeruli but also how they drive disease when their expression is dysregulated. Finally, we review how manipulating VEGF and Angpt signalling may be used to treat glomerular disease.

Original languageEnglish
Pages (from-to)1225-1236
Number of pages12
JournalClinical Science
Volume129
Issue number12
DOIs
Publication statusPublished - 2015

Keywords

  • Angiopoietins
  • Endothelial cells
  • Glomerulus
  • Permeability
  • Podocytes
  • Vascular endothelial growth factor (VEGF)

ASJC Scopus subject areas

  • Medicine(all)

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