Vascular inflammation and endothelial dysfunction in experimental hypertension

Carmine Savoia, Lidia Sada, Luigi Zezza, Lorenzo Pucci, Francesco Maria Lauri, Alberto Befani, Alessandro Alonzo, Massimo Volpe

Research output: Contribution to journalArticlepeer-review


Essential hypertension is characterized by increased peripheral vascular resistance to blood flow. The endothelium is a crucial regulator of vascular tone. Its function is impaired in patients with hypertension, with reduced vasodilation, increased vascular tone associated with a proinflammatory and prothrombotic state. Low-grade inflammation localized in vascular tissue is therefore recognized as an important contributor to the pathophysiology of hypertension, to the initiation and progression of atherosclerosis as well as to the development of cardiovascular diseases.

Original languageEnglish
Article number281240
JournalInternational Journal of Hypertension
Publication statusPublished - 2011

ASJC Scopus subject areas

  • Internal Medicine


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