Vascular Issues in Neurodegeneration and Injury

L. Longhi, E. R. Zanier, V. Conte, N. Stocchetti, T. K. McIntosh

Research output: Chapter in Book/Report/Conference proceedingChapter


Traumatic brain injury (TBI) is one of the leading causes of injury-related deaths in the Western hemisphere. Traumatic brain damage is a result of direct (immediate mechanical disruption of brain tissue, or primary injury) and indirect (delayed or secondary) mechanisms. Secondary injuries, because of their delayed onset and progression over minutes to months after the initial trauma, are potentially amenable to postinjury therapeutic intervention. Vascular pathology and alterations in cerebral blood flow are major contributors to mortality and morbidity following TBI. This article summarizes the pathology of vascular disruptions following TBI, the time course and major mechanisms of posttraumatic cerebral blood flow alterations, and the influence of genetic susceptibility to vascular changes after TBI.

Original languageEnglish
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Number of pages9
ISBN (Print)9780080450469
Publication statusPublished - 2010


  • Brain trauma
  • Cerebral blood flow
  • Ischemia
  • Pathophysiology

ASJC Scopus subject areas

  • Neuroscience(all)


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