Vascular, metabolic, and inflammatory abnormalities in normoglycemic offspring of patients with type 2 diabetes mellitus

Manfredi Tesauro, Stefano Rizza, Micaela Iantorno, Umberto Campia, Carmine Cardillo, Davide Lauro, Roberto Leo, Mario Turriziani, Giulio Cesare Cocciolillo, Angelo Fusco, Julio A. Panza, Angelo Scuteri, Massimo Federici, Renato Lauro, Michael J. Quon

Research output: Contribution to journalArticle

Abstract

Endothelial dysfunction, insulin resistance, and elevated levels of circulating proinflammatory markers are among the earliest detectable abnormalities in people at risk for atherosclerosis. Accelerated atherosclerosis is a leading contributor to morbidity and mortality in type 2 diabetes mellitus, a complex genetic disorder. Therefore, we hypothesized that normoglycemic offspring of patients with type 2 diabetes mellitus (NOPD) may have impaired vascular and metabolic function related to an enhanced proinflammatory state. We compared NOPD (n = 51) with matched healthy control subjects without family history of diabetes (n = 35). Flow- and nitroglycerin-mediated brachial artery vasodilation were assessed by ultrasound to evaluate endothelium-dependent and -independent vascular function. Each subject also underwent an oral glucose tolerance test to evaluate metabolic function. Fasting levels of plasma adiponectin and circulating markers of inflammation (high-sensitivity C-reactive protein, CD40 ligand, interleukin 1β, tumor necrosis factor α, vascular cell adhesion molecule 1, and intracellular adhesion molecule) were measured. Both NOPD and the control group had fasting glucose and insulin levels well within the reference range. However, results from oral glucose tolerance test and quantitative insulin sensitivity check index revealed that NOPD were insulin resistant with significantly impaired flow- and nitroglycerin-mediated dilation compared with the control group. Adiponectin levels were lower, whereas many circulating markers of inflammation were higher, in NOPD compared with the control group. Normoglycemic offspring of patients with type 2 diabetes mellitus have impaired vascular and metabolic function accompanied by an enhanced proinflammatory state that may contribute to their increased risk of diabetes and its vascular complications.

Original languageEnglish
Pages (from-to)413-419
Number of pages7
JournalMetabolism
Volume56
Issue number3
DOIs
Publication statusPublished - Mar 2007

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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    Tesauro, M., Rizza, S., Iantorno, M., Campia, U., Cardillo, C., Lauro, D., Leo, R., Turriziani, M., Cocciolillo, G. C., Fusco, A., Panza, J. A., Scuteri, A., Federici, M., Lauro, R., & Quon, M. J. (2007). Vascular, metabolic, and inflammatory abnormalities in normoglycemic offspring of patients with type 2 diabetes mellitus. Metabolism, 56(3), 413-419. https://doi.org/10.1016/j.metabol.2006.10.026