Vascular phenotype in angiogenic and non-angiogenic lung non-small cell carcinomas

E. Passalidou, M. Trivella, N. Singh, M. Ferguson, J. Hu, A. Cesario, P. Granone, A. G. Nicholson, P. Goldstraw, C. Ratcliffe, M. Tetlow, I. Leigh, A. L. Harris, K. C. Garter, F. Pezzella

Research output: Contribution to journalArticlepeer-review

Abstract

We have previously described a group of non-small cell lung carcinomas without morphological evidence of neo-angiogenesis. In these tumours neoplastic cells fill up the alveoli and the only vessels present appear to belong to the trapped alveolar septa. In the present study we have characterised the phenotype of the vessels present in these non-angiogenic tumours, in normal lung and in angiogenic non-small cell lung carcinomas. The vessels, identified by the expression of CD31, were scored as mature when expressing the epitope LH39 in the basal membrane and as newly formed when expressing αVβ3 on the endothelial cells and/or lacking LH39 expression. In the nine putative non-angiogenic cases examined, the vascular phenotype of all the vessels was the same as that of alveolar vessels in normal lung: LH39 positive and αVβ3 variable or negative. Instead in 104 angiogenic tumours examined, only a minority of vessels (mean 13.1%; range 0-60%) expressed LH39, while αVβ3 (in 45 cases) was strongly expressed on many vessels (mean 55.5%; range 5-90%). We conclude that in putative non-angiogenic tumours the vascular phenotype is that of normal vessels and there is no neo-angiogenesis. This type of cancer may be resistant to some anti-angiogenic therapy and different strategies need to be developed.

Original languageEnglish
Pages (from-to)244-249
Number of pages6
JournalBritish Journal of Cancer
Volume86
Issue number2
DOIs
Publication statusPublished - Jan 21 2002

Keywords

  • Angiogenesis
  • Lung cancer
  • Vascular phenotype

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Fingerprint

Dive into the research topics of 'Vascular phenotype in angiogenic and non-angiogenic lung non-small cell carcinomas'. Together they form a unique fingerprint.

Cite this