Vascular risk factors, alcohol intake, and cognitive decline

F. Panza, C. Capurso, A. D'Introno, A. M. Colacicco, V. Frisardi, A. Santamato, M. Ranieri, P. Fiore, G. Vendemiale, D. Seripa, A. Pilotto, A. Capurso, V. Solfrizzi

Research output: Contribution to journalArticle

Abstract

Since the therapeutic options currently available have demonstrated limited efficacy, the search for preventive strategies for cognitive decline and dementia is mandatory, A possible role of vascular and lifestyle-related factors was recently proposed for age-related changes of cognitive function, predementia syndromes, and cognitive decline of degenerative (Alzheimer's disease, AD) or vascular origin. At present, cumulative evidence suggested that vascular risk factors may be important in the development of mild cognitive impairment (MCI), dementia, and AD. Among vascular-related factors, metabolic syndrome has been associated with the risk of cognitive decline and overall dementia. Moderate alcohol drinking has been proposed as a protective factor against MCI and dementia in several longitudinal studies, but contrasting findings also exist. However, in most cases, these were only observational studies, and results are awaited from large multicenter randomized clinical trials in older persons. At present, vascular risk factor management, lifestyle changes, and drugs could be employed together to delay the onset of dementia syndromes.

Original languageEnglish
Pages (from-to)376-381
Number of pages6
JournalJournal of Nutrition, Health and Aging
Volume12
Issue number6
DOIs
Publication statusPublished - Jun 2008

Keywords

  • Alcohol
  • Alzheimer's disease
  • Dementia
  • Metabolic syndrome
  • Mild cognitive impairment
  • Predementia syndromes
  • Vascular dementia
  • Vascular risk factors

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Ageing
  • Endocrinology
  • Food Science

Fingerprint Dive into the research topics of 'Vascular risk factors, alcohol intake, and cognitive decline'. Together they form a unique fingerprint.

  • Cite this

    Panza, F., Capurso, C., D'Introno, A., Colacicco, A. M., Frisardi, V., Santamato, A., Ranieri, M., Fiore, P., Vendemiale, G., Seripa, D., Pilotto, A., Capurso, A., & Solfrizzi, V. (2008). Vascular risk factors, alcohol intake, and cognitive decline. Journal of Nutrition, Health and Aging, 12(6), 376-381. https://doi.org/10.1007/BF02982669