Vascular risk factors in mild cognitive impairment subtypes: Findings from the ReGAl project

E. Mariani, R. Monastero, S. Ercolani, F. Mangialasche, M. Caputo, F. T. Feliziani, D. F. Vitale, U. Senin, P. Mecocci

Research output: Contribution to journalArticlepeer-review


Background and Aim: To investigate the role of vascular risk factors in different subtypes of mild cognitive impairment (MCI) in a multicentric, clinic-based, cross-sectional study. Methods: Two-hundred and seven subjects with MCI were included in the study: 33 with single non-memory MCI (snmMCI), 42 with multiple-domain amnestic MCI (mdMCI-a) and 132 with amnestic MCI (aMCI). Several clinical vascular risk factors and magnetic resonance imaging (MRI) brain lesions were evaluated. Results: snmMCI showed a higher frequency of ischaemic heart disease and of transient ischaemic attack (TIA)/stroke, a higher Hachinski ischaemic score and a higher frequency of white-matter lesions on MRI compared to aMCI. Subjects with mdMCI-a showed clinical characteristics similar to aMCI, except for a higher frequency of a history of TIA/stroke. Conclusion: Our findings suggest that snmMCI may be considered a vascular cognitive disorder.

Original languageEnglish
Pages (from-to)448-456
Number of pages9
JournalDementia and Geriatric Cognitive Disorders
Issue number6
Publication statusPublished - Nov 2007


  • Cognitive impairment
  • Mild cognitive impairment subtypes
  • Vascular risk factors
  • White-matter lesions

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Geriatrics and Gerontology


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