Vascular tumor targeting

J. Ahlskog, G. Paganelli, D. Neri

Research output: Contribution to journalArticle

Abstract

The growth of solid tumors is dependent on their capacity to acquire blood supply. Therefore, much effort has been directed towards the development of anti-angiogenic agents which inhibit the process of neovascularization. More recently, it has become apparent that the targeted destruction of the established tumor vasculature represents a complementary avenue for growing therapeutic opportunities. This review provides evidence that vascular tumor targeting is an effective anti-tumor strategy in animal models. It further describes strategies for the identification of putative tumor vascular targets and discusses future prospects for vascular targeting applications in the clinical setting.

Original languageEnglish
Pages (from-to)296-309
Number of pages14
JournalQuarterly Journal of Nuclear Medicine and Molecular Imaging
Volume50
Issue number4
Publication statusPublished - Dec 2006

Keywords

  • Endothelium vascular
  • Neoplasms
  • Radiopharmaceuticals
  • Tumor targeting

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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