Vascular tumors in pediatric age. The experience of the Italian and German Cooperative Group

A. Ferrari, M. Casanova, C. Meazza, G. Bisogno, P. Dall'igna, A. Mattke, D. Kunz, J. Treuner, A. Donfrancesco, P. Indolfi, M. Carli

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives. Malignant vascular tumors are an unusual finding in pediatric age; therefore, scanty data on their clinical management and treatment are available. We report a series of 58 pediatric patients treated between 1980 and 2000 by an Italian and German Cooperative Group. Patients and methods. Our cohort comprised 11 patients with angiosarcoma (AS), 2 with Kaposi's sarcoma, 18 with hemangioendothelioma (HE), and 27 with hemangiopericytoma (HP). Surgical excision was the basic treatment; radiotherapy was administered to 22 patients, chemotherapy to 46, interferon to 3. Results. 5-yr EFS was 22.7% for AS, 85.7% for infantile HP, 69% for adult HP, 60.6% for HE. Conclusions. Prognosis and clinical management change in the different subtypes. Patients with AS have a poor outcome and require new treatment strategies; infantile HP has a very good prognosis, probably close to infantile myofibromatosis; in adult HP chemotherapy and radiotherapy could be reserved to unresectable and large/aggressive tumors; in patients with HE, interferon seems more effective than standard chemotherapy. Intergroup cooperation is required to improve the knowledge of these tumors.

Original languageEnglish
Pages (from-to)774-778
Number of pages5
JournalItalian Journal of Pediatrics
Volume27
Issue number5
Publication statusPublished - Oct 2001

Keywords

  • Angiosarcoma
  • Childhood vascular tumor
  • Hemangioendothelioma
  • Hemangiopericytoma
  • Kaposi's sarcoma
  • Soft tissue sarcoma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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