Vascular tumors in pediatric age. The experience of the Italian and German Cooperative Group

A. Ferrari, M. Casanova, C. Meazza, G. Bisogno, P. Dall'igna, A. Mattke, D. Kunz, J. Treuner, A. Donfrancesco, P. Indolfi, M. Carli

Research output: Contribution to journalArticle

Abstract

Objectives. Malignant vascular tumors are an unusual finding in pediatric age; therefore, scanty data on their clinical management and treatment are available. We report a series of 58 pediatric patients treated between 1980 and 2000 by an Italian and German Cooperative Group. Patients and methods. Our cohort comprised 11 patients with angiosarcoma (AS), 2 with Kaposi's sarcoma, 18 with hemangioendothelioma (HE), and 27 with hemangiopericytoma (HP). Surgical excision was the basic treatment; radiotherapy was administered to 22 patients, chemotherapy to 46, interferon to 3. Results. 5-yr EFS was 22.7% for AS, 85.7% for infantile HP, 69% for adult HP, 60.6% for HE. Conclusions. Prognosis and clinical management change in the different subtypes. Patients with AS have a poor outcome and require new treatment strategies; infantile HP has a very good prognosis, probably close to infantile myofibromatosis; in adult HP chemotherapy and radiotherapy could be reserved to unresectable and large/aggressive tumors; in patients with HE, interferon seems more effective than standard chemotherapy. Intergroup cooperation is required to improve the knowledge of these tumors.

Original languageEnglish
Pages (from-to)774-778
Number of pages5
JournalItalian Journal of Pediatrics
Volume27
Issue number5
Publication statusPublished - Oct 2001

Fingerprint

Hemangiopericytoma
Blood Vessels
Pediatrics
Hemangioendothelioma
Hemangiosarcoma
Neoplasms
Drug Therapy
Interferons
Radiotherapy
Kaposi's Sarcoma
Therapeutics

Keywords

  • Angiosarcoma
  • Childhood vascular tumor
  • Hemangioendothelioma
  • Hemangiopericytoma
  • Kaposi's sarcoma
  • Soft tissue sarcoma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Vascular tumors in pediatric age. The experience of the Italian and German Cooperative Group. / Ferrari, A.; Casanova, M.; Meazza, C.; Bisogno, G.; Dall'igna, P.; Mattke, A.; Kunz, D.; Treuner, J.; Donfrancesco, A.; Indolfi, P.; Carli, M.

In: Italian Journal of Pediatrics, Vol. 27, No. 5, 10.2001, p. 774-778.

Research output: Contribution to journalArticle

Ferrari, A, Casanova, M, Meazza, C, Bisogno, G, Dall'igna, P, Mattke, A, Kunz, D, Treuner, J, Donfrancesco, A, Indolfi, P & Carli, M 2001, 'Vascular tumors in pediatric age. The experience of the Italian and German Cooperative Group', Italian Journal of Pediatrics, vol. 27, no. 5, pp. 774-778.
Ferrari, A. ; Casanova, M. ; Meazza, C. ; Bisogno, G. ; Dall'igna, P. ; Mattke, A. ; Kunz, D. ; Treuner, J. ; Donfrancesco, A. ; Indolfi, P. ; Carli, M. / Vascular tumors in pediatric age. The experience of the Italian and German Cooperative Group. In: Italian Journal of Pediatrics. 2001 ; Vol. 27, No. 5. pp. 774-778.
@article{938ce32788de457197e7259083ac037b,
title = "Vascular tumors in pediatric age. The experience of the Italian and German Cooperative Group",
abstract = "Objectives. Malignant vascular tumors are an unusual finding in pediatric age; therefore, scanty data on their clinical management and treatment are available. We report a series of 58 pediatric patients treated between 1980 and 2000 by an Italian and German Cooperative Group. Patients and methods. Our cohort comprised 11 patients with angiosarcoma (AS), 2 with Kaposi's sarcoma, 18 with hemangioendothelioma (HE), and 27 with hemangiopericytoma (HP). Surgical excision was the basic treatment; radiotherapy was administered to 22 patients, chemotherapy to 46, interferon to 3. Results. 5-yr EFS was 22.7{\%} for AS, 85.7{\%} for infantile HP, 69{\%} for adult HP, 60.6{\%} for HE. Conclusions. Prognosis and clinical management change in the different subtypes. Patients with AS have a poor outcome and require new treatment strategies; infantile HP has a very good prognosis, probably close to infantile myofibromatosis; in adult HP chemotherapy and radiotherapy could be reserved to unresectable and large/aggressive tumors; in patients with HE, interferon seems more effective than standard chemotherapy. Intergroup cooperation is required to improve the knowledge of these tumors.",
keywords = "Angiosarcoma, Childhood vascular tumor, Hemangioendothelioma, Hemangiopericytoma, Kaposi's sarcoma, Soft tissue sarcoma",
author = "A. Ferrari and M. Casanova and C. Meazza and G. Bisogno and P. Dall'igna and A. Mattke and D. Kunz and J. Treuner and A. Donfrancesco and P. Indolfi and M. Carli",
year = "2001",
month = "10",
language = "English",
volume = "27",
pages = "774--778",
journal = "Italian Journal of Pediatrics",
issn = "1720-8424",
publisher = "BioMed Central Ltd.",
number = "5",

}

TY - JOUR

T1 - Vascular tumors in pediatric age. The experience of the Italian and German Cooperative Group

AU - Ferrari, A.

AU - Casanova, M.

AU - Meazza, C.

AU - Bisogno, G.

AU - Dall'igna, P.

AU - Mattke, A.

AU - Kunz, D.

AU - Treuner, J.

AU - Donfrancesco, A.

AU - Indolfi, P.

AU - Carli, M.

PY - 2001/10

Y1 - 2001/10

N2 - Objectives. Malignant vascular tumors are an unusual finding in pediatric age; therefore, scanty data on their clinical management and treatment are available. We report a series of 58 pediatric patients treated between 1980 and 2000 by an Italian and German Cooperative Group. Patients and methods. Our cohort comprised 11 patients with angiosarcoma (AS), 2 with Kaposi's sarcoma, 18 with hemangioendothelioma (HE), and 27 with hemangiopericytoma (HP). Surgical excision was the basic treatment; radiotherapy was administered to 22 patients, chemotherapy to 46, interferon to 3. Results. 5-yr EFS was 22.7% for AS, 85.7% for infantile HP, 69% for adult HP, 60.6% for HE. Conclusions. Prognosis and clinical management change in the different subtypes. Patients with AS have a poor outcome and require new treatment strategies; infantile HP has a very good prognosis, probably close to infantile myofibromatosis; in adult HP chemotherapy and radiotherapy could be reserved to unresectable and large/aggressive tumors; in patients with HE, interferon seems more effective than standard chemotherapy. Intergroup cooperation is required to improve the knowledge of these tumors.

AB - Objectives. Malignant vascular tumors are an unusual finding in pediatric age; therefore, scanty data on their clinical management and treatment are available. We report a series of 58 pediatric patients treated between 1980 and 2000 by an Italian and German Cooperative Group. Patients and methods. Our cohort comprised 11 patients with angiosarcoma (AS), 2 with Kaposi's sarcoma, 18 with hemangioendothelioma (HE), and 27 with hemangiopericytoma (HP). Surgical excision was the basic treatment; radiotherapy was administered to 22 patients, chemotherapy to 46, interferon to 3. Results. 5-yr EFS was 22.7% for AS, 85.7% for infantile HP, 69% for adult HP, 60.6% for HE. Conclusions. Prognosis and clinical management change in the different subtypes. Patients with AS have a poor outcome and require new treatment strategies; infantile HP has a very good prognosis, probably close to infantile myofibromatosis; in adult HP chemotherapy and radiotherapy could be reserved to unresectable and large/aggressive tumors; in patients with HE, interferon seems more effective than standard chemotherapy. Intergroup cooperation is required to improve the knowledge of these tumors.

KW - Angiosarcoma

KW - Childhood vascular tumor

KW - Hemangioendothelioma

KW - Hemangiopericytoma

KW - Kaposi's sarcoma

KW - Soft tissue sarcoma

UR - http://www.scopus.com/inward/record.url?scp=17544379091&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=17544379091&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:17544379091

VL - 27

SP - 774

EP - 778

JO - Italian Journal of Pediatrics

JF - Italian Journal of Pediatrics

SN - 1720-8424

IS - 5

ER -