Vascularized retinal pigment epithelial detachment in age-related macular degeneration: Treatment and RPE tear incidence

Ugo Introini; Ana Torres Gimeno; Fabrizio Scotti; Marco Setaccioli; Silvia Giatsidis; Francesco Bandello

doi:10.1007/s00417-012-1955-2

Vascularized retinal pigment epithelial detachment in age-related macular degeneration: Treatment and RPE tear incidence

Ugo Introini, Ana Torres Gimeno, Fabrizio Scotti, Marco Setaccioli, Silvia Giatsidis, Francesco Bandello

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Background To review vascularized-pigment epithelial detachment (V-PED) treatment visual outcome, and to assess acute retinal pigment epithelium (RPE) tear incidence. Methods One hundred and thirty-two eyes of 125 consecutive patients with age-related macular degeneration and V-PED were included. Ninety-four eyes (71.2%) were associated with choroidal new vessels (CNV), 38 (28.8%) with retinal angiomatous proliferation (RAP). Patients, treated over a 10-year period with the time-current therapy, received: verteporfin photodynamic therapy (PDT) (group 1, 38 eyes), combined intravitreal triamcinolone acetonide (IVTA) and PDT (group 2, 44 eyes) or intravitreal anti-VEGF injection (bevacizumab or ranibizumab) (group 3, 50 eyes). Results Mean follow-up was 20.5 months. At month 12, all eyes treated with PDTor with IVTA and PDTshowed a mean significant severe visual decrease. Eyes with CNV lost -0.67 and -0.37 logMAR (p

Original language	English
Pages (from-to)	1283-1292
Number of pages	10
Journal	Graefe's Archive for Clinical and Experimental Ophthalmology
Volume	250
Issue number	9
DOIs	https://doi.org/10.1007/s00417-012-1955-2
Publication status	Published - Sep 2012

Keywords

Age-related macular degeneration
Antivegf
Choroidal neovascularization
Retinal angiomatous proliferation
Retinal pigment epithelial detachment
Rpe tear

ASJC Scopus subject areas

Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience

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10.1007/s00417-012-1955-2

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title = "Vascularized retinal pigment epithelial detachment in age-related macular degeneration: Treatment and RPE tear incidence",

abstract = "Background To review vascularized-pigment epithelial detachment (V-PED) treatment visual outcome, and to assess acute retinal pigment epithelium (RPE) tear incidence. Methods One hundred and thirty-two eyes of 125 consecutive patients with age-related macular degeneration and V-PED were included. Ninety-four eyes (71.2%) were associated with choroidal new vessels (CNV), 38 (28.8%) with retinal angiomatous proliferation (RAP). Patients, treated over a 10-year period with the time-current therapy, received: verteporfin photodynamic therapy (PDT) (group 1, 38 eyes), combined intravitreal triamcinolone acetonide (IVTA) and PDT (group 2, 44 eyes) or intravitreal anti-VEGF injection (bevacizumab or ranibizumab) (group 3, 50 eyes). Results Mean follow-up was 20.5 months. At month 12, all eyes treated with PDTor with IVTA and PDTshowed a mean significant severe visual decrease. Eyes with CNV lost -0.67 and -0.37 logMAR (p",

keywords = "Age-related macular degeneration, Antivegf, Choroidal neovascularization, Retinal angiomatous proliferation, Retinal pigment epithelial detachment, Rpe tear",

author = "Ugo Introini and {Torres Gimeno}, Ana and Fabrizio Scotti and Marco Setaccioli and Silvia Giatsidis and Francesco Bandello",

year = "2012",

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T1 - Vascularized retinal pigment epithelial detachment in age-related macular degeneration

T2 - Treatment and RPE tear incidence

AU - Introini, Ugo

AU - Torres Gimeno, Ana

AU - Scotti, Fabrizio

AU - Setaccioli, Marco

AU - Giatsidis, Silvia

AU - Bandello, Francesco

PY - 2012/9

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N2 - Background To review vascularized-pigment epithelial detachment (V-PED) treatment visual outcome, and to assess acute retinal pigment epithelium (RPE) tear incidence. Methods One hundred and thirty-two eyes of 125 consecutive patients with age-related macular degeneration and V-PED were included. Ninety-four eyes (71.2%) were associated with choroidal new vessels (CNV), 38 (28.8%) with retinal angiomatous proliferation (RAP). Patients, treated over a 10-year period with the time-current therapy, received: verteporfin photodynamic therapy (PDT) (group 1, 38 eyes), combined intravitreal triamcinolone acetonide (IVTA) and PDT (group 2, 44 eyes) or intravitreal anti-VEGF injection (bevacizumab or ranibizumab) (group 3, 50 eyes). Results Mean follow-up was 20.5 months. At month 12, all eyes treated with PDTor with IVTA and PDTshowed a mean significant severe visual decrease. Eyes with CNV lost -0.67 and -0.37 logMAR (p

AB - Background To review vascularized-pigment epithelial detachment (V-PED) treatment visual outcome, and to assess acute retinal pigment epithelium (RPE) tear incidence. Methods One hundred and thirty-two eyes of 125 consecutive patients with age-related macular degeneration and V-PED were included. Ninety-four eyes (71.2%) were associated with choroidal new vessels (CNV), 38 (28.8%) with retinal angiomatous proliferation (RAP). Patients, treated over a 10-year period with the time-current therapy, received: verteporfin photodynamic therapy (PDT) (group 1, 38 eyes), combined intravitreal triamcinolone acetonide (IVTA) and PDT (group 2, 44 eyes) or intravitreal anti-VEGF injection (bevacizumab or ranibizumab) (group 3, 50 eyes). Results Mean follow-up was 20.5 months. At month 12, all eyes treated with PDTor with IVTA and PDTshowed a mean significant severe visual decrease. Eyes with CNV lost -0.67 and -0.37 logMAR (p

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KW - Retinal pigment epithelial detachment

KW - Rpe tear

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Vascularized retinal pigment epithelial detachment in age-related macular degeneration: Treatment and RPE tear incidence

Abstract

Keywords

ASJC Scopus subject areas

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