Vasculitis of the gastrointestinal tract in chronic periaortitis

Carlo Salvarani, Kenneth T. Calamia, Eric L. Matteson, Gene G. Hunder, Nicolò Pipitone, Dylan V. Miller, Kenneth J. Warrington

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Abstract

The term "chronic periaortitis" (CP), proposed by Mitchinson in 1984, comprises 3 main entities: idiopathic retroperitoneal fibrosis (IRF), inflammatory abdominal aortic aneurysms (IAAAs), and perianeurysmal retroperitoneal fibrosis (PRF).The presence of constitutional symptoms, high acute-phase reactants, positive autoantibodies, and associated autoimmune diseases suggests a systemic inflammatory process. Histopathologic findings show vasculitis with fibrinoid necrosis involving the aortic vasa vasorum as well as the small and medium retroperitoneal vessels.We reviewed the medical records of 608 patients with a diagnosis of vasculitis involving the gastrointestinal (GI) tract at the Mayo Clinic between January 1996 and December 2007. Only patients with biopsy-proven or typical angiographic findings of vasculitis localized to the GI tract were included.Five patients were identified with evidence of CP (1 patient with PRF, 1 with IRF, and 3 with IAAAs). Three patients were men, and the median age at diagnosis was 49 years. The diagnosis of GI vasculitis and CP was made simultaneously in 4 patients. At the time of onset, all patients had abdominal pain and constitutional manifestations; the median erythrocyte sedimentation rate was 62.5 mm/1 h (range, 20-86 mm/1 h). All patients had evidence of mesenteric vasculitis at angiography. Three patients also had associated renal artery stenoses. Abdominal computed tomography showed spleen infarcts in 2 patients, bowel wall thickening in 1, and liver infarction in 1. Two patients underwent surgical intervention for acute abdomen; there was histologic evidence of small bowel infarcts and infarction of the spleen and liver in 1. Oral prednisone was administered to all 5 patients (median starting dose, 60 mg/d; range, 25-80 mg/d). Three patients also received immunosuppressive agents, 1 tamoxifen, and 1 anti-tumor necrosis factor therapy. All patients had at least 1 relapse or recurrence of vasculitis, but at last visit, GI vasculitis and CP were in remission in all 5 patients.This study provides evidence that GI manifestations due to mesenteric vasculitis may be associated with CP. Vasculitic involvement of the renal arteries is also frequently present in these patients. Aggressive immunosuppressive treatment should be promptly initiated to forestall abdominal complications. These findings reinforce the hypothesis that a vasculitic process plays an important role in the pathogenesis of CP.

Original languageEnglish
Pages (from-to)28-39
Number of pages12
JournalMedicine (United States)
Volume90
Issue number1
DOIs
Publication statusPublished - Jan 2011

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Retroperitoneal Fibrosis
Vasculitis
Gastrointestinal Tract
Splenic Infarction
Abdominal Aortic Aneurysm
Immunosuppressive Agents
Infarction
Vasa Vasorum
Recurrence
Renal Artery Obstruction
Acute Abdomen
Acute-Phase Proteins
Liver
Blood Sedimentation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Salvarani, C., Calamia, K. T., Matteson, E. L., Hunder, G. G., Pipitone, N., Miller, D. V., & Warrington, K. J. (2011). Vasculitis of the gastrointestinal tract in chronic periaortitis. Medicine (United States), 90(1), 28-39. https://doi.org/10.1097/MD.0b013e318207231e

Vasculitis of the gastrointestinal tract in chronic periaortitis. / Salvarani, Carlo; Calamia, Kenneth T.; Matteson, Eric L.; Hunder, Gene G.; Pipitone, Nicolò; Miller, Dylan V.; Warrington, Kenneth J.

In: Medicine (United States), Vol. 90, No. 1, 01.2011, p. 28-39.

Research output: Contribution to journalArticle

Salvarani, C, Calamia, KT, Matteson, EL, Hunder, GG, Pipitone, N, Miller, DV & Warrington, KJ 2011, 'Vasculitis of the gastrointestinal tract in chronic periaortitis', Medicine (United States), vol. 90, no. 1, pp. 28-39. https://doi.org/10.1097/MD.0b013e318207231e
Salvarani, Carlo ; Calamia, Kenneth T. ; Matteson, Eric L. ; Hunder, Gene G. ; Pipitone, Nicolò ; Miller, Dylan V. ; Warrington, Kenneth J. / Vasculitis of the gastrointestinal tract in chronic periaortitis. In: Medicine (United States). 2011 ; Vol. 90, No. 1. pp. 28-39.
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