Vasoactive intestinal peptide (VIP) cells in the pancreas and gastro-intestinal mucosa - Am Immunohistochemical and ultrastructural study

R. Buffa, C. Capella, E. Solcia, B. Frigerio, S. I. Said

Research output: Contribution to journalArticlepeer-review

Abstract

Using antibodies against pure porcine VIP in immunoperoxidase and immunofluorescence tests, VIP-immunoreactive cells have been detected in the pancreas-especially in the islets-and gastrointestinal mucosa of the dog, guinea-pig and man. VIP immunoreactive cells were widely distributed in these tissues, never being numerous at any site. Some parallelism has been noted between such cells and ultrastructurally identified D1 cells of the pancreas and gastrointestinal mucosa. The presence of VIP cells in normal pancreas may help explain the occurrence of pancreatic endocrine tumors producing VIP.

Original languageEnglish
Pages (from-to)217-227
Number of pages11
JournalHistochemistry
Volume50
Issue number3
DOIs
Publication statusPublished - Sep 1977

ASJC Scopus subject areas

  • Anatomy

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