Vasopressin release and water metabolism in patients with cirrhosis

Francesco Salerno, Alberto DelBo, Alessandra Maggi, Monica Marabini, Maria Maffi, GianMario Borroni, Pamela Moser

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Water retention is a complication in many patients with cirrhosis, usually attributed to excessive release of arginine vasopressin. To investigate the responsiveness of arginine vasopressin to osmotic and non-osmotic stimuli and its relationship to free water excretion, we studied 19 patients with cirrhosis under three different conditions: 45 min with legs raised to 60°, to expand the central blood volume; infusion of 1000 ml of 0.45% saline solution to reduce plasma osmolality; and rapid injection of 50 ml of 2 M NaCl to increase plasma osmolality. Both expansion of central blood volume and decrease of plasma osmolality significantly reduced plasma vasopressin levels (from 2.1±0.6 to 1.39±0.3 pg/ml, p

Original languageEnglish
Pages (from-to)822-830
Number of pages9
JournalJournal of Hepatology
Volume21
Issue number5
DOIs
Publication statusPublished - 1994

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Vasopressins
Osmolar Concentration
Fibrosis
Arginine Vasopressin
Water
Plasma Volume
Blood Volume
Sodium Chloride
Leg
Injections

Keywords

  • Kidney
  • Osmolality
  • Sodium

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Salerno, F., DelBo, A., Maggi, A., Marabini, M., Maffi, M., Borroni, G., & Moser, P. (1994). Vasopressin release and water metabolism in patients with cirrhosis. Journal of Hepatology, 21(5), 822-830. https://doi.org/10.1016/S0168-8278(94)80245-9

Vasopressin release and water metabolism in patients with cirrhosis. / Salerno, Francesco; DelBo, Alberto; Maggi, Alessandra; Marabini, Monica; Maffi, Maria; Borroni, GianMario; Moser, Pamela.

In: Journal of Hepatology, Vol. 21, No. 5, 1994, p. 822-830.

Research output: Contribution to journalArticle

Salerno, F, DelBo, A, Maggi, A, Marabini, M, Maffi, M, Borroni, G & Moser, P 1994, 'Vasopressin release and water metabolism in patients with cirrhosis', Journal of Hepatology, vol. 21, no. 5, pp. 822-830. https://doi.org/10.1016/S0168-8278(94)80245-9
Salerno F, DelBo A, Maggi A, Marabini M, Maffi M, Borroni G et al. Vasopressin release and water metabolism in patients with cirrhosis. Journal of Hepatology. 1994;21(5):822-830. https://doi.org/10.1016/S0168-8278(94)80245-9
Salerno, Francesco ; DelBo, Alberto ; Maggi, Alessandra ; Marabini, Monica ; Maffi, Maria ; Borroni, GianMario ; Moser, Pamela. / Vasopressin release and water metabolism in patients with cirrhosis. In: Journal of Hepatology. 1994 ; Vol. 21, No. 5. pp. 822-830.
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