Vasostatins exert negative inotropism in the working heart of the frog

A. Corti, C. Mannarino, R. Mazza, B. Colombo, R. Longhi, B. Tota

Research output: Contribution to journalArticlepeer-review


An in vitro isolated working frog heart (Rana esculenta) was used to study the effects of exogenous CGA1-76 (vasostatin 1), CGA1-113 (vasostatin 2), and the synthetic CGA7-57 on cardiac performance. Under basal cardiac conditions, the dose-response curves of the three peptides from 10-8 to 10-7 M showed a significant calcium-dependent negative inotropism that involved neither the endocardial endothelium nor the adrenergic and muscarinic receptors. In addition, the CgA fragments clearly counteracted the typical positive inotropism of isoprenaline (10-9 M). Taken together, these results provide the first evidence for a cardio-suppressive role for the vasostatins.

Original languageEnglish
Pages (from-to)362-365
Number of pages4
JournalAnnals of the New York Academy of Sciences
Publication statusPublished - Jun 5 2002

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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