Vasostatins exert negative inotropism in the working heart of the frog

A. Corti; C. Mannarino; R. Mazza; B. Colombo; R. Longhi; B. Tota

Vasostatins exert negative inotropism in the working heart of the frog

A. Corti, C. Mannarino, R. Mazza, B. Colombo, R. Longhi, B. Tota

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

An in vitro isolated working frog heart (Rana esculenta) was used to study the effects of exogenous CGA_1-76 (vasostatin 1), CGA_1-113 (vasostatin 2), and the synthetic CGA_7-57 on cardiac performance. Under basal cardiac conditions, the dose-response curves of the three peptides from 10^-8 to 10^-7 M showed a significant calcium-dependent negative inotropism that involved neither the endocardial endothelium nor the adrenergic and muscarinic receptors. In addition, the CgA fragments clearly counteracted the typical positive inotropism of isoprenaline (10^-9 M). Taken together, these results provide the first evidence for a cardio-suppressive role for the vasostatins.

Original language	English
Pages (from-to)	362-365
Number of pages	4
Journal	Annals of the New York Academy of Sciences
Volume	971
Publication status	Published - Jun 5 2002

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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abstract = "An in vitro isolated working frog heart (Rana esculenta) was used to study the effects of exogenous CGA1-76 (vasostatin 1), CGA1-113 (vasostatin 2), and the synthetic CGA7-57 on cardiac performance. Under basal cardiac conditions, the dose-response curves of the three peptides from 10-8 to 10-7 M showed a significant calcium-dependent negative inotropism that involved neither the endocardial endothelium nor the adrenergic and muscarinic receptors. In addition, the CgA fragments clearly counteracted the typical positive inotropism of isoprenaline (10-9 M). Taken together, these results provide the first evidence for a cardio-suppressive role for the vasostatins.",

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AU - Corti, A.

AU - Mannarino, C.

AU - Mazza, R.

AU - Colombo, B.

AU - Longhi, R.

AU - Tota, B.

PY - 2002/6/5

Y1 - 2002/6/5

N2 - An in vitro isolated working frog heart (Rana esculenta) was used to study the effects of exogenous CGA1-76 (vasostatin 1), CGA1-113 (vasostatin 2), and the synthetic CGA7-57 on cardiac performance. Under basal cardiac conditions, the dose-response curves of the three peptides from 10-8 to 10-7 M showed a significant calcium-dependent negative inotropism that involved neither the endocardial endothelium nor the adrenergic and muscarinic receptors. In addition, the CgA fragments clearly counteracted the typical positive inotropism of isoprenaline (10-9 M). Taken together, these results provide the first evidence for a cardio-suppressive role for the vasostatins.

AB - An in vitro isolated working frog heart (Rana esculenta) was used to study the effects of exogenous CGA1-76 (vasostatin 1), CGA1-113 (vasostatin 2), and the synthetic CGA7-57 on cardiac performance. Under basal cardiac conditions, the dose-response curves of the three peptides from 10-8 to 10-7 M showed a significant calcium-dependent negative inotropism that involved neither the endocardial endothelium nor the adrenergic and muscarinic receptors. In addition, the CgA fragments clearly counteracted the typical positive inotropism of isoprenaline (10-9 M). Taken together, these results provide the first evidence for a cardio-suppressive role for the vasostatins.

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JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

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Vasostatins exert negative inotropism in the working heart of the frog

Abstract

ASJC Scopus subject areas

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