Vegetable hierarchical structures as template for bone regeneration: New bio-ceramization process for the development of a bone scaffold applied to an experimental sheep model

Giuseppe Filardo, Alice Roffi, Tobias Fey, Milena Fini, Gianluca Giavaresi, Maurilio Marcacci, Julian Martínez-Fernández, Lucia Martini, Joaquin Ramírez-Rico, Francesca Salamanna, Monica Sandri, Simone Sprio, Anna Tampieri, Elizaveta Kon

Research output: Contribution to journalArticle

Abstract

Long bone defects still represent a major clinical challenge in orthopedics, with the inherent loss of function considerably impairing the quality of life of the affected patients. Thus, the purpose of this study was to assess the safety and potential of bone regeneration offered by a load-bearing scaffold characterized by unique hierarchical architecture and high strength, with active surface facilitating new bone penetration and osseointegration in critical size bone defects. The results of this study showed the potential of bio-ceramization processes applied to vegetable hierarchical structures for the production of new wood-derived bone scaffolds, further improved by surface functionalization, with good biological and mechanical properties leading to successful treatment of critical size bone defects in the sheep model. Future studies are needed to evaluate if these scaffolds prototypes, as either biomaterial alone or in combination with augmentation strategies, may represent an optimal solution to enhance bone regeneration in humans.

Original languageEnglish
Pages (from-to)1-12
Number of pages12
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
DOIs
Publication statusE-pub ahead of print - 2020

Keywords

  • bio-ceramization
  • bone regeneration
  • hierarchical structure
  • long bone defect
  • scaffold

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