VEGF-A gene promoter polymorphisms and microvascular complications in patients with essential hypertension

Raffaele Palmirotta; Patrizia Ferroni; Giorgia Ludovici; Francesca Martini; Annalisa Savonarola; Roberta D'Alessandro; Valeria Raparelli; Marco Proietti; Antongiulio Scarno; Silvia Riondino; Stefania Basili; Fiorella Guadagni

doi:10.1016/j.clinbiochem.2010.06.020

VEGF-A gene promoter polymorphisms and microvascular complications in patients with essential hypertension

Raffaele Palmirotta, Patrizia Ferroni, Giorgia Ludovici, Francesca Martini, Annalisa Savonarola, Roberta D'Alessandro, Valeria Raparelli, Marco Proietti, Antongiulio Scarno, Silvia Riondino, Stefania Basili, Fiorella Guadagni

Istituto San Raffaele Pisana

Research output: Contribution to journal › Article › peer-review

Abstract

Objectives: We investigated the possible involvement of vascular endothelial growth factor (VEGF-A) gene promoter polymorphisms in essential hypertension (EH). Design and methods: 1225. bp of the VEGF-A gene promoter were screened for polymorphisms using PCR amplification and direct DNA sequence analysis in 62 EH and 62 normotensive (HS) individuals. Circulating VEGF-A levels were determined by immunoassay. Results: -152G/A (p=0.009) and -116G/A (p=0.016) polymorphisms were correlated to hypertension (p

Original language	English
Pages (from-to)	1090-1095
Number of pages	6
Journal	Clinical Biochemistry
Volume	43
Issue number	13-14
DOIs	https://doi.org/10.1016/j.clinbiochem.2010.06.020
Publication status	Published - Sep 2010

Keywords

Essential hypertension
VEGF-A
VEGF-A polymorphisms

ASJC Scopus subject areas

Clinical Biochemistry

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10.1016/j.clinbiochem.2010.06.020

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Palmirotta, R., Ferroni, P., Ludovici, G., Martini, F., Savonarola, A., D'Alessandro, R., Raparelli, V., Proietti, M., Scarno, A., Riondino, S., Basili, S., & Guadagni, F. (2010). VEGF-A gene promoter polymorphisms and microvascular complications in patients with essential hypertension. Clinical Biochemistry, 43(13-14), 1090-1095. https://doi.org/10.1016/j.clinbiochem.2010.06.020

Palmirotta, R, Ferroni, P, Ludovici, G, Martini, F, Savonarola, A, D'Alessandro, R, Raparelli, V, Proietti, M, Scarno, A, Riondino, S, Basili, S & Guadagni, F 2010, 'VEGF-A gene promoter polymorphisms and microvascular complications in patients with essential hypertension', Clinical Biochemistry, vol. 43, no. 13-14, pp. 1090-1095. https://doi.org/10.1016/j.clinbiochem.2010.06.020

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abstract = "Objectives: We investigated the possible involvement of vascular endothelial growth factor (VEGF-A) gene promoter polymorphisms in essential hypertension (EH). Design and methods: 1225. bp of the VEGF-A gene promoter were screened for polymorphisms using PCR amplification and direct DNA sequence analysis in 62 EH and 62 normotensive (HS) individuals. Circulating VEGF-A levels were determined by immunoassay. Results: -152G/A (p=0.009) and -116G/A (p=0.016) polymorphisms were correlated to hypertension (p",

keywords = "Essential hypertension, VEGF-A, VEGF-A polymorphisms",

author = "Raffaele Palmirotta and Patrizia Ferroni and Giorgia Ludovici and Francesca Martini and Annalisa Savonarola and Roberta D'Alessandro and Valeria Raparelli and Marco Proietti and Antongiulio Scarno and Silvia Riondino and Stefania Basili and Fiorella Guadagni",

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doi = "10.1016/j.clinbiochem.2010.06.020",

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AU - Palmirotta, Raffaele

AU - Ferroni, Patrizia

AU - Ludovici, Giorgia

AU - Martini, Francesca

AU - Savonarola, Annalisa

AU - D'Alessandro, Roberta

AU - Raparelli, Valeria

AU - Proietti, Marco

AU - Scarno, Antongiulio

AU - Riondino, Silvia

AU - Basili, Stefania

AU - Guadagni, Fiorella

PY - 2010/9

Y1 - 2010/9

N2 - Objectives: We investigated the possible involvement of vascular endothelial growth factor (VEGF-A) gene promoter polymorphisms in essential hypertension (EH). Design and methods: 1225. bp of the VEGF-A gene promoter were screened for polymorphisms using PCR amplification and direct DNA sequence analysis in 62 EH and 62 normotensive (HS) individuals. Circulating VEGF-A levels were determined by immunoassay. Results: -152G/A (p=0.009) and -116G/A (p=0.016) polymorphisms were correlated to hypertension (p

AB - Objectives: We investigated the possible involvement of vascular endothelial growth factor (VEGF-A) gene promoter polymorphisms in essential hypertension (EH). Design and methods: 1225. bp of the VEGF-A gene promoter were screened for polymorphisms using PCR amplification and direct DNA sequence analysis in 62 EH and 62 normotensive (HS) individuals. Circulating VEGF-A levels were determined by immunoassay. Results: -152G/A (p=0.009) and -116G/A (p=0.016) polymorphisms were correlated to hypertension (p

KW - Essential hypertension

KW - VEGF-A

KW - VEGF-A polymorphisms

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VEGF-A gene promoter polymorphisms and microvascular complications in patients with essential hypertension

Abstract

Keywords

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