TY - JOUR
T1 - VEGF-A gene promoter polymorphisms and microvascular complications in patients with essential hypertension
AU - Palmirotta, Raffaele
AU - Ferroni, Patrizia
AU - Ludovici, Giorgia
AU - Martini, Francesca
AU - Savonarola, Annalisa
AU - D'Alessandro, Roberta
AU - Raparelli, Valeria
AU - Proietti, Marco
AU - Scarno, Antongiulio
AU - Riondino, Silvia
AU - Basili, Stefania
AU - Guadagni, Fiorella
PY - 2010/9
Y1 - 2010/9
N2 - Objectives: We investigated the possible involvement of vascular endothelial growth factor (VEGF-A) gene promoter polymorphisms in essential hypertension (EH). Design and methods: 1225. bp of the VEGF-A gene promoter were screened for polymorphisms using PCR amplification and direct DNA sequence analysis in 62 EH and 62 normotensive (HS) individuals. Circulating VEGF-A levels were determined by immunoassay. Results: -152G/A (p=0.009) and -116G/A (p=0.016) polymorphisms were correlated to hypertension (p
AB - Objectives: We investigated the possible involvement of vascular endothelial growth factor (VEGF-A) gene promoter polymorphisms in essential hypertension (EH). Design and methods: 1225. bp of the VEGF-A gene promoter were screened for polymorphisms using PCR amplification and direct DNA sequence analysis in 62 EH and 62 normotensive (HS) individuals. Circulating VEGF-A levels were determined by immunoassay. Results: -152G/A (p=0.009) and -116G/A (p=0.016) polymorphisms were correlated to hypertension (p
KW - Essential hypertension
KW - VEGF-A
KW - VEGF-A polymorphisms
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U2 - 10.1016/j.clinbiochem.2010.06.020
DO - 10.1016/j.clinbiochem.2010.06.020
M3 - Article
C2 - 20621078
AN - SCOPUS:77956170105
VL - 43
SP - 1090
EP - 1095
JO - Clinical Biochemistry
JF - Clinical Biochemistry
SN - 0009-9120
IS - 13-14
ER -