TY - JOUR
T1 - VEGF gene and phenotype relation with Alzheimer's disease and mild cognitive impairment
AU - Chiappelli, Martina
AU - Borroni, Barbara
AU - Archetti, Silvana
AU - Calabrese, Elena
AU - Corsi, Massimiliano M.
AU - Franceschi, Massimo
AU - Padovani, Alessandro
AU - Licastro, Federico
PY - 2006/12
Y1 - 2006/12
N2 - Background: The expression of vascular endothelial growth factor (VEGF) represents one potential mechanism whereby vascular and Alzheimer's disease (AD) pathologies are related. The authors investigated whether AD cases, especially those having a rapid cognitive decline, more commonly carried a functional promoter gene variant for VEGF (-2578C/A) and showed elevated plasma levels of Vegf. In addition, the authors investigated whether patterns of association also were found for mild cognitive impairment (MCI) and conversion from MCI to AD. Methods: Group 1 included 317 AD cases and 320 unaffected control subjects. Group 2 included 113 MCI patients and 130 control subjects. Plasma levels of Vegf were measured by chemiluminescence for a subset of group 1. Genotype determinations were made for all subjects. Findings: The VEGF AA genotype was associated with an increased risk of developing AD (OR = 1.616, p = 0.046). This genotype also was associated with an accelerated cognitive decline in APOE ε4 positive patients with AD (AA vs. CC OR = 6.5, p = 0.04). The VEGF AA genotype was a risk factor for MCI (OR = 2.5, p = 0.037) and MCI conversion to AD in APOE ε4 + (OR = 6.5, CI = 2.014-20.980; p = 0.002). Vegf plasma levels were higher in patients with AD than controls (230 pg/mL vs. 42 pg/mL), and were even higher in those patients with a fast cognitive decline and the APOE ε4 allele. Interpretation: Modulation of VEGF expression is a potential mechanism associated with the risk of developing AD and its clinical deterioration.
AB - Background: The expression of vascular endothelial growth factor (VEGF) represents one potential mechanism whereby vascular and Alzheimer's disease (AD) pathologies are related. The authors investigated whether AD cases, especially those having a rapid cognitive decline, more commonly carried a functional promoter gene variant for VEGF (-2578C/A) and showed elevated plasma levels of Vegf. In addition, the authors investigated whether patterns of association also were found for mild cognitive impairment (MCI) and conversion from MCI to AD. Methods: Group 1 included 317 AD cases and 320 unaffected control subjects. Group 2 included 113 MCI patients and 130 control subjects. Plasma levels of Vegf were measured by chemiluminescence for a subset of group 1. Genotype determinations were made for all subjects. Findings: The VEGF AA genotype was associated with an increased risk of developing AD (OR = 1.616, p = 0.046). This genotype also was associated with an accelerated cognitive decline in APOE ε4 positive patients with AD (AA vs. CC OR = 6.5, p = 0.04). The VEGF AA genotype was a risk factor for MCI (OR = 2.5, p = 0.037) and MCI conversion to AD in APOE ε4 + (OR = 6.5, CI = 2.014-20.980; p = 0.002). Vegf plasma levels were higher in patients with AD than controls (230 pg/mL vs. 42 pg/mL), and were even higher in those patients with a fast cognitive decline and the APOE ε4 allele. Interpretation: Modulation of VEGF expression is a potential mechanism associated with the risk of developing AD and its clinical deterioration.
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U2 - 10.1089/rej.2006.9.485
DO - 10.1089/rej.2006.9.485
M3 - Article
C2 - 17105389
AN - SCOPUS:33846228854
VL - 9
SP - 485
EP - 493
JO - Rejuvenation Research
JF - Rejuvenation Research
SN - 1549-1684
IS - 4
ER -