Venous angioplasty in patients with multiple sclerosis: Results of a pilot study

P. Zamboni, R. Galeotti, B. Weinstock-Guttman, C. Kennedy, F. Salvi, R. Zivadinov

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: Chronic cerebrospinal venous insufficiency (CCSVI) is associated with multiple sclerosis (MS). The objective of the study was to see if percutaneous transluminal angioplasty (PTA) of duplex-detected lesions, of the internal jugular and/or azygous veins, was safe, burdened by a significant restenosis rate, and whether there was any evidence that treatment reduced MS disease activity. Design: This was a case-control study. Materials: We studied 15 patients with relapsing-remitting MS and duplex-detected CCSVI. Methods: Eight patients had PTA in addition to medical therapy (immediate treatment group (ITG)), whereas seven had treatment with PTA after 6 months of medical therapy alone (delayed treatment group (DTG)). Results: No adverse events occurred. At 1 year, there was a restenosis rate of 27%. Overall, PTA was followed by a significant improvement in functional score compared with baseline (p <0.02). The annualised relapse rate was 0.12% in the ITG compared with 0.66% in the DTG (p = NS). Magnetic resonance imaging (MRI) blindly demonstrates a trend for fewer T2 lesions in the ITG (p = 0.081), corresponding to a 10% decrease in the ITG compared with a 23% increase in the DTG over the first 6 months of the study. Conclusions: This study further confirms the safety of PTA treatment in patients with CCSVI associated with MS. The results, despite the significant rate of restenosis, are encouraging and warrant a larger multicentre double-blinded, randomised study.

Original languageEnglish
Pages (from-to)116-122
Number of pages7
JournalEuropean Journal of Vascular and Endovascular Surgery
Volume43
Issue number1
DOIs
Publication statusPublished - Jan 2012

Keywords

  • Chronic cerebrospinal venous insufficiency
  • Multiple sclerosis
  • Percutaneous transluminal angioplasty

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

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