Venous Thromboembolism in Women Undergoing Assisted Reproductive Technologies: Data from the RIETE Registry

Elvira Grandone, Pier Paolo Di Micco, Michela Villani, Donatella Colaizzo, Carmen Fernández-Capitán, Jorge Del Toro, Vladimir Rosa, Alessandra Bura-Riviere, Isabelle Quere, Ángeles Blanco-Molina, Maurizio Margaglione, Manuel Monreal

Research output: Contribution to journalArticlepeer-review


Venous thromboembolism (VTE) during or after assisted reproductive technologies (ART) is predicted to rise due to the increased number of women undergoing this technique. We present data collected in the RIETE registry up to October 2016. Overall, 41 (0.6%) out of 6,718 women of childbearing age with VTE had an ART-related event. Most of them underwent autologous ART cycles; 23 had isolated deep vein thrombosis (DVT) (56.1%), 12 isolated pulmonary embolism (PE) (29.3%) and 6 simultaneous occurrence of both the events (14.6%). VTE occurred in 20 successful and 21 unsuccessful (i.e. not resulting in a clinical pregnancy) ART cycles. No recurrence was observed at 90 days. Logistic regression showed that isolated PE was significantly more frequent than DVT alone or combined with PE in unsuccessful in vitro fertilization (IVF) (odds ratio [OR]: 4.13, 95% confidence interval [CI]: 1.4-12.4), as well as in contraceptive users (OR: 2.96, 95% CI: 1.95-4.5) and in puerperium (OR: 1.96, 95% CI: 1.16-3.3). After grouping isolated PE and DVT + PE, we found that PE was significantly more frequent in women with unsuccessful IVF and higher body mass index (OR: 5.0, 95% CI: 1.2-20.7 and OR: 1.0, 95%CI: 1.0-1.1, respectively). These data document a higher risk of PE in unsuccessful cycles than in successful ones. The risk is higher than that observed during pregnancy, puerperium and contraception.

Original languageEnglish
Pages (from-to)1962-1968
Number of pages7
JournalThrombosis and Haemostasis
Issue number11
Publication statusPublished - Jan 1 2018


  • assisted reproductive technologies
  • pregnancy
  • venous thromboembolism

ASJC Scopus subject areas

  • Hematology


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