Venous thrombosis and procoagulant factors in high-risk neuroblastoma

Amalia Schiavetti, Micaela Foco, Damiano Chiriacó, Metello Iacobini, Giulia Varrasso, Annapaola Ingrosso, Laura Conti

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Aim: The mechanism of increased thrombin production has been investigated in children with high-risk neuroblastoma (NB), to detect any possible association between catheter- related venous thrombosis (VT) and prothrombotic factors. Methods: Consecutive children with high-risk NB were studied by color-doppler ultrasonography of the upper vein system and thrombophilia factors assessment. Plasma levels of Tissue Factor (TF), Vascular Endothelial Growth Factor (VEGF), Prothrombin Activation Fragment 1+2, and Thrombin-Antithrombin Complex were evaluated. Moreover, inherited thrombophilia factors (homocystein, antithrombin, protein C, protein S, factor V Leiden, activated protein C resistence, mutation H1299R and G1691A of factor V, mutation G20210A of prothrombin, mutation T677 and A1298C of methylenetetrahydrofolate reductase, and allele 4G of plasminogen activator inhibitor-1) were tested to exclude congenital disorders. Results: Six patients with mean age: 48.8 months - were studied. Five patients were affected by stage 4 NB and another one by stage 3 NB with Myc-N amplification. All children had a central venous line (mean duration: 8.5 mos). Four patients (67%) had asymptomatic catheter-related VT visualized by color-doppler ultrasonography. No patient had major inherited thrombophilia factors. The levels of plasma TF and plasma VEGF were found elevated in all patients. Mean value of TF (nv 20.3±6.6) was 82 pg/mL with a range of 39 to 131 pg/mL. Mean value of VEGF (nv 24.3 pg/mL) was 78.5 pg/mL with a range of 31 to 142 pg/mL. Conclusion: The increased risk of catheter-related VT detected in our small series of high-risk NB patients, was associated with elevated levels of circulating TF and VEGF. Further studies are needed to evaluate if elevated levels of TF/VEGF are involved both in the hypercoagulable state and in advanced childhood cancer.

Original languageEnglish
Pages (from-to)93-96
Number of pages4
JournalJournal of Pediatric Hematology/Oncology
Volume32
Issue number2
DOIs
Publication statusPublished - Mar 2010

Fingerprint

Neuroblastoma
Venous Thrombosis
Thromboplastin
Vascular Endothelial Growth Factor A
Thrombophilia
Doppler Color Ultrasonography
Catheters
Protein C
Mutation
Antithrombin Proteins
Methylenetetrahydrofolate Reductase (NADPH2)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Protein S
Plasminogen Activator Inhibitor 1
Prothrombin
Thrombin
Veins
Alleles
Neoplasms

Keywords

  • Neuroblastoma
  • Thrombosis
  • Tissue factor
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Hematology

Cite this

Venous thrombosis and procoagulant factors in high-risk neuroblastoma. / Schiavetti, Amalia; Foco, Micaela; Chiriacó, Damiano; Iacobini, Metello; Varrasso, Giulia; Ingrosso, Annapaola; Conti, Laura.

In: Journal of Pediatric Hematology/Oncology, Vol. 32, No. 2, 03.2010, p. 93-96.

Research output: Contribution to journalArticle

Schiavetti, A, Foco, M, Chiriacó, D, Iacobini, M, Varrasso, G, Ingrosso, A & Conti, L 2010, 'Venous thrombosis and procoagulant factors in high-risk neuroblastoma', Journal of Pediatric Hematology/Oncology, vol. 32, no. 2, pp. 93-96. https://doi.org/10.1097/MPH.0b013e3181cc8a1e
Schiavetti A, Foco M, Chiriacó D, Iacobini M, Varrasso G, Ingrosso A et al. Venous thrombosis and procoagulant factors in high-risk neuroblastoma. Journal of Pediatric Hematology/Oncology. 2010 Mar;32(2):93-96. https://doi.org/10.1097/MPH.0b013e3181cc8a1e
Schiavetti, Amalia ; Foco, Micaela ; Chiriacó, Damiano ; Iacobini, Metello ; Varrasso, Giulia ; Ingrosso, Annapaola ; Conti, Laura. / Venous thrombosis and procoagulant factors in high-risk neuroblastoma. In: Journal of Pediatric Hematology/Oncology. 2010 ; Vol. 32, No. 2. pp. 93-96.
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