Ventilator-associated pneumonia in an Italian pediatric intensive care unit: A prospective study

Maria Francesca Patria, Giovanna Chidini, Ludovica Ughi, Cinzia Montani, Edi Prandi, Carlotta Galeone, Edoardo Calderini, Susanna Esposito

Research output: Contribution to journalArticlepeer-review


Background: This study was undertaken to determine the prevalence, risk factors and outcomes associated with ventilator-associated pneumonia (VAP) in a European pediatric intensive care unit (PICU). Methods: A total of 451 children who had been mechanically ventilated in the PICU for ≥48 hours during a 3-year period were enrolled in this prospective study. Results: In comparison with children without VAP, 30 children (6.6%) who developed VAP had a longer PICU stay (P=0.0001) and hospital stay (P=0.0001), and a higher mortality rate (P=0.04). Logistic regression analysis showed that the need for re-intubation (P=0.0001), the presence of tracheostomy (P=0.04), and enteral feeding (P=0.02) were independent risk factors for VAP. Conclusions: A relevant proportion of intubated children develop VAP, which is closely related to invasive procedures. As VAP is associated with increased medical costs and death, multicenter studies are urgently needed to improve the therapeutic approach to VAP and VAP prevention.

Original languageEnglish
Pages (from-to)365-368
Number of pages4
JournalWorld Journal of Pediatrics
Issue number4
Publication statusPublished - Nov 2013


  • nosocomial infections
  • pneumonia
  • ventilator-associated pneumonia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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