TY - JOUR
T1 - Ventral premotor to primary motor cortical interactions during noxious and naturalistic action observation
AU - Lago, Angel
AU - Koch, Giacomo
AU - Cheeran, Binith
AU - Márquez, Gonzalo
AU - Sánchez, Jose Andrés
AU - Ezquerro, Milagros
AU - Giraldez, Manolo
AU - Fernández-del-Olmo, Miguel
PY - 2010/5
Y1 - 2010/5
N2 - Within the motor system, cortical areas such as the primary motor cortex (M1) and the ventral premotor cortex (PMv), are thought to be activated during the observation of actions performed by others. However, it is not known how the connections between these areas become active during action observation or whether these connections are modulated by the volitional component induced by the action observed. In this study, using a paired pulse transcranial magnetic stimulation (ppTMS) method, we evaluated the excitability of PMv-M1 connections during the observation of videos showing a human hand reaching to grasp a ball (naturalistic grasping video) or a switched on soldering iron (noxious grasping video). The results show that the observation of the naturalistic grasping action increased the M1 excitability and changed the strength of the PMv-M1 connections. The observation of the noxious grasping action did not induce any change in the excitability of the PMv-M1 connections throughout the video, but the strength of PMv-M1 connectivity was reduced. These results demonstrate that the PMv-M1 connections are modulated differently depending on whether the action observed would or would not be performed in real life.
AB - Within the motor system, cortical areas such as the primary motor cortex (M1) and the ventral premotor cortex (PMv), are thought to be activated during the observation of actions performed by others. However, it is not known how the connections between these areas become active during action observation or whether these connections are modulated by the volitional component induced by the action observed. In this study, using a paired pulse transcranial magnetic stimulation (ppTMS) method, we evaluated the excitability of PMv-M1 connections during the observation of videos showing a human hand reaching to grasp a ball (naturalistic grasping video) or a switched on soldering iron (noxious grasping video). The results show that the observation of the naturalistic grasping action increased the M1 excitability and changed the strength of the PMv-M1 connections. The observation of the noxious grasping action did not induce any change in the excitability of the PMv-M1 connections throughout the video, but the strength of PMv-M1 connectivity was reduced. These results demonstrate that the PMv-M1 connections are modulated differently depending on whether the action observed would or would not be performed in real life.
KW - Action observation
KW - Mirror system
KW - Reaching
KW - Transcranial magnetic stimulation
KW - Ventral premotor cortex
UR - http://www.scopus.com/inward/record.url?scp=77952543584&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77952543584&partnerID=8YFLogxK
U2 - 10.1016/j.neuropsychologia.2010.02.030
DO - 10.1016/j.neuropsychologia.2010.02.030
M3 - Article
C2 - 20223253
AN - SCOPUS:77952543584
VL - 48
SP - 1802
EP - 1806
JO - Neuropsychologia
JF - Neuropsychologia
SN - 0028-3932
IS - 6
ER -