Ventral Tegmental Area in Prodromal Alzheimer's Disease: Bridging the Gap between Mice and Humans

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Abstract

Alzheimer's disease (AD) is a progressive neurological disorder characterized by several cognitive and non-cognitive symptoms, with episodic memory being the earliest and most prominently impaired cognitive function. Dopaminergic signals are required for encoding hippocampal memory for new events and the ventral tegmental area (VTA), together with the locus coeruleus, are the primary sources of dopamine acting on dopaminergic receptors in the hippocampus. With this in mind, a recent study on a validated mouse model of AD highlighted on the hippocampal dysfunction and its correlation with an early degeneration of dopaminergic neurons in the VTA. In this issue, De Marco and Venneri test the hypothesis that the volume of the VTA nucleus in humans might be associated with cognitive features of AD.

Original languageEnglish
Pages (from-to)181-183
Number of pages3
JournalJournal of Alzheimer's disease : JAD
Volume63
Issue number1
DOIs
Publication statusPublished - 2018

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Ventral Tegmental Area
Alzheimer Disease
Tegmentum Mesencephali
Locus Coeruleus
Episodic Memory
Dopaminergic Neurons
Nervous System Diseases
Cognition
Hippocampus
Dopamine

Cite this

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title = "Ventral Tegmental Area in Prodromal Alzheimer's Disease: Bridging the Gap between Mice and Humans",
abstract = "Alzheimer's disease (AD) is a progressive neurological disorder characterized by several cognitive and non-cognitive symptoms, with episodic memory being the earliest and most prominently impaired cognitive function. Dopaminergic signals are required for encoding hippocampal memory for new events and the ventral tegmental area (VTA), together with the locus coeruleus, are the primary sources of dopamine acting on dopaminergic receptors in the hippocampus. With this in mind, a recent study on a validated mouse model of AD highlighted on the hippocampal dysfunction and its correlation with an early degeneration of dopaminergic neurons in the VTA. In this issue, De Marco and Venneri test the hypothesis that the volume of the VTA nucleus in humans might be associated with cognitive features of AD.",
author = "Marcello D'Amelio and Laura Serra and Marco Bozzali",
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doi = "10.3233/JAD-180094",
language = "English",
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journal = "Journal of Alzheimer's Disease",
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TY - JOUR

T1 - Ventral Tegmental Area in Prodromal Alzheimer's Disease

T2 - Bridging the Gap between Mice and Humans

AU - D'Amelio, Marcello

AU - Serra, Laura

AU - Bozzali, Marco

PY - 2018

Y1 - 2018

N2 - Alzheimer's disease (AD) is a progressive neurological disorder characterized by several cognitive and non-cognitive symptoms, with episodic memory being the earliest and most prominently impaired cognitive function. Dopaminergic signals are required for encoding hippocampal memory for new events and the ventral tegmental area (VTA), together with the locus coeruleus, are the primary sources of dopamine acting on dopaminergic receptors in the hippocampus. With this in mind, a recent study on a validated mouse model of AD highlighted on the hippocampal dysfunction and its correlation with an early degeneration of dopaminergic neurons in the VTA. In this issue, De Marco and Venneri test the hypothesis that the volume of the VTA nucleus in humans might be associated with cognitive features of AD.

AB - Alzheimer's disease (AD) is a progressive neurological disorder characterized by several cognitive and non-cognitive symptoms, with episodic memory being the earliest and most prominently impaired cognitive function. Dopaminergic signals are required for encoding hippocampal memory for new events and the ventral tegmental area (VTA), together with the locus coeruleus, are the primary sources of dopamine acting on dopaminergic receptors in the hippocampus. With this in mind, a recent study on a validated mouse model of AD highlighted on the hippocampal dysfunction and its correlation with an early degeneration of dopaminergic neurons in the VTA. In this issue, De Marco and Venneri test the hypothesis that the volume of the VTA nucleus in humans might be associated with cognitive features of AD.

U2 - 10.3233/JAD-180094

DO - 10.3233/JAD-180094

M3 - Article

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JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

SN - 1387-2877

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ER -