Ventricular fibrillation in six adults without overt heart disease

Robert Lemery, Pedro Brugada, Paolo Della Bella, Thierry Dugernier, Hein J J Wellens

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Findings are described in six patients with no clinical evidence of heart disease who had documented ventricular fibrillation (five patients) or ventricular flutter (one patient). The mean age of the six patients, all men, was 34 years (range 26 to 43). Cardiovascular collapse occurred in all and was followed by successful cardioversion. No patient had electrolyte or QT abnormalities. One patient had slight right ventricular enlargement on M-mode echocardiography, and another had a left ventricular pressure gradient at rest of 30 mm Hg with a normal two-dimensional echocardiogram. Holter electrocardiographic monitoring revealed incessant ventricular tachycardia in one patient and nonsustained ventricular tachycardia in three others. Exercise testing revealed nonsustained ventricular tachycardia in one patient. Ventricular fibrillation was induced at the time of programmed electrical stimulation in four of the six patients. Documented recurrence of ventricular fibrillation or ventricular flutter occurred in three patients, but in only one patient receiving antiarrhythmic drugs. Four patients were treated with amiodarone and one received an automatic implantable cardioverter-defibrillator. All patients are alive after a mean follow-up period of 78 months after the first documentation of their arrhythmia and 37 months after programmed electrical stimulation. Ventricular fibrillation can occur in the apparently structurally normal human heart. Antiarrhythmic treatment can provide effective control of this malignant arrhythmia.

Original languageEnglish
Pages (from-to)911-916
Number of pages6
JournalJournal of the American College of Cardiology
Volume13
Issue number4
DOIs
Publication statusPublished - Mar 15 1989

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Ventricular Fibrillation
Heart Diseases
Ventricular Flutter
Ventricular Tachycardia
Electric Stimulation
Cardiac Arrhythmias
Electric Countershock
Ambulatory Electrocardiography
Amiodarone
Implantable Defibrillators
Anti-Arrhythmia Agents
Ventricular Pressure
Documentation
Electrolytes
Echocardiography
Exercise

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Ventricular fibrillation in six adults without overt heart disease. / Lemery, Robert; Brugada, Pedro; Della Bella, Paolo; Dugernier, Thierry; Wellens, Hein J J.

In: Journal of the American College of Cardiology, Vol. 13, No. 4, 15.03.1989, p. 911-916.

Research output: Contribution to journalArticle

Lemery, Robert ; Brugada, Pedro ; Della Bella, Paolo ; Dugernier, Thierry ; Wellens, Hein J J. / Ventricular fibrillation in six adults without overt heart disease. In: Journal of the American College of Cardiology. 1989 ; Vol. 13, No. 4. pp. 911-916.
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