Ventricular Tachycardia Ablation in Severe Heart Failure: An International Ventricular Tachycardia Ablation Center Collaboration Analysis

WS Tzou, R Tung, DS Frankel, M Vaseghi, T Jared Bunch, Luigi Di Biase, VN Tholakanahalli, D Lakkireddy, T Dickfeld, A Saliaris, J Peter Weiss, N Mathuria, U Tedrow, MR Afzal, P Vergara, K Nagashima, M Patel, S Nakahara, K Vakil, J David BurkhardtCH Tseng, Andrea Natale, K Shivkumar, DJ Callans, WG Stevenson, P Della Bella, FE Marchlinski, WH Sauer

Research output: Contribution to journalArticlepeer-review

Abstract

Background - Ventricular tachycardia (VT) radiofrequency ablation has been associated with reduced VT recurrence and mortality, although it is typically not considered among New York Heart Association class IV (NYHA IV) heart failure patients. We compared characteristics and VT radiofrequency ablation outcomes of those with and without NYHA IV in the International VT Ablation Center Collaboration. Methods and Results - NYHA II-IV patients undergoing VT radiofrequency ablation at 12 international centers were included. Clinical variables, VT recurrence, and mortality were analyzed by NYHA IV status using Kaplan-Meier analysis and Cox proportional hazard models. There were significant differences between NYHA IV (n=111) and NYHA II and III (n=1254) patients: NYHA IV had lower left ventricular ejection fraction; more had diabetes mellitus, kidney disease, cardiac resynchronization implantable cardioverter-defibrillator, and VT storm despite greater antiarrhythmic drug use (P
Original languageEnglish
Article numbere004494
JournalCirculation: Arrhythmia and Electrophysiology
Volume10
Issue number1
DOIs
Publication statusPublished - 2017

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