Verapamil and propranolol: A comparison of two antihypertensive agents

G. Leonetti, C. Pasotti, G. P. Ferrari, A. Zanchetti

Research output: Contribution to journalArticlepeer-review


Verapamil, a calcium antagonist, was compared with propranolol, a widely used beta-adrenoreceptor blocker, in hypertensive patients with respect to its antihypertensive efficacy and incidence and severity of adverse effects. Both drugs caused similar blood pressure reductions without interfering with pulse pressure. The hypotensive effect of verapamil was not accompanied by any effect on heart rate, while after verapamil there was a significant bradycardia. ST-segment and T wave abnormalities at rest and after aldosterone were partially or completely reverted by both drugs. The incidence and severity of adverse effects was very low and no patient was withdrawn from the study because of complaints due to the active drugs. Verapamil can be compared as antihypertensive drug to the beta-blocker propranolol and thus may justify, together with the absence of negative effects on lipids, blood suger, serum electolytes and renal function, its use as an antihypertensive drug of first choice.

Original languageEnglish
Pages (from-to)137-141
Number of pages5
JournalActa Medica Scandinavica
Issue numberSUPPL. 681
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Internal Medicine
  • Medicine(all)


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