Verapamil prevents the acute hypertensive response to intracerebroventricular cadmium in conscious normotensive rats

Paolo Madeddu, Maria Piera Demontis, Maria Vittoria Varoni, Maria Caterina Fattaccio, Alessandra Palmieri, Vittorio Anania

Research output: Contribution to journalArticle

Abstract

Cadmium, a trace element from natural and industrial sources, may contribute to the pathogenesis of arterial hypertension. We evaluated the effect induced by acute intracerebroventricular (icv) administration of cadmium on mean blood pressure of normotensive conscious rats. Intracerebroventricular cadmium (1 to 10 fig) produced a dose-dependent, sustained increase in mean blood pressure. The hypertensive response to icv cadmium was significantly (P <.01) prevented by icv pretreatment with verapamil (10 to 100 fig). A preventive effect was exerted also by icv nifedipine (100 fig); however, this result was attributable, at least in part, to the antihypertensive action of the vehicle, polyethylene glycol. The hypertensive response to icv cadmium was blunted by icv administration of 10 ng clonidine, 10 fig vasopressin antagonist, or 10 fig bradykinin antagonist (P <.05), but it was not altered by icv enalaprilat (100 fig). These results indicate that brain calcium channels play a role in the hypertensive action induced by icv cadmium. Accumulation of cadmium in the brain caused by prolonged exposure to this heavy metal might lead to chronic arterial hypertension. Am J Hypertens 1993;6:193-197.

Original languageEnglish
Pages (from-to)193-197
Number of pages5
JournalAmerican Journal of Hypertension
Volume6
Issue number3
DOIs
Publication statusPublished - 1993

Fingerprint

Ficus
Verapamil
Cadmium
Enalaprilat
Blood Pressure
Hypertension
Brain
Trace Elements
Clonidine
Calcium Channels
Nifedipine
Heavy Metals
Antihypertensive Agents

Keywords

  • Cadmium
  • Calcium-antagonists
  • Central nervous system
  • Hypertension

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Verapamil prevents the acute hypertensive response to intracerebroventricular cadmium in conscious normotensive rats. / Madeddu, Paolo; Demontis, Maria Piera; Varoni, Maria Vittoria; Fattaccio, Maria Caterina; Palmieri, Alessandra; Anania, Vittorio.

In: American Journal of Hypertension, Vol. 6, No. 3, 1993, p. 193-197.

Research output: Contribution to journalArticle

Madeddu, Paolo ; Demontis, Maria Piera ; Varoni, Maria Vittoria ; Fattaccio, Maria Caterina ; Palmieri, Alessandra ; Anania, Vittorio. / Verapamil prevents the acute hypertensive response to intracerebroventricular cadmium in conscious normotensive rats. In: American Journal of Hypertension. 1993 ; Vol. 6, No. 3. pp. 193-197.
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